Xanthan Gum in Medical Field Applications

xanthan gum pharmaceutical uses/applications are as follows:

Pharmaceutical Excipient

Xanthan gum was included in the Chinese Pharmacopoeia as a pharmaceutical
excipient in 2010. Compared with other gums and suspending agents,
pharmaceutical grade xanthan gum has high viscosity (especially significant at
low concentrations), strong rheology and pseudoplastic, excellent stability,
acid and alkali resistance, enzyme resistance, good compatibility and
adaptability with various solvents, and safe and non-toxic characteristics. As
a result, xanthan gum has very good pharmaceutical applications.

Xanthan gum is a functional component that is popular among microcapsule drugs
in the international sections, which plays an important role in controlling the
sustainable release of drugs. Due to its own strong hydrophilicity and water
retention, there are many specific medical operations and applications, such as
forming a dense water film to avoid skin infections; reducing the thirst of
patients after radiotherapy. Xanthan gum itself can significantly enhance
humoral immune function. The application in medicine is as a stabilizer, which
can be used in various suspension concentrations and emulsifiers, such as
vitamin emulsifiers to avoid delamination caused by temperature rise. Xanthan
gum is easily soluble in cold water, making it is easier to make solution
preparation. As a thickener, xanthan gum can be used to make tablets that can
extend the contact time with other additives.

Deosen recommended type: PM80/200

Recommended dosage: 0.01%---0.05%

Preparation of Liquid and semi-solid medicine

Xanthan gum can be used as an effective thickener, suspending agent,
emulsifier, and stabilizer in the multiphase system of liquid and semi-solid
preparations. The pseudo-plasticity of xanthan gum makes it easier to apply in
external medicine preparations. The drug is not easy to fall off from the skin
after water volatilization, thereby improving the bioavailability of the drug
and the comfort of medication.

Taking calamine lotion bifonazole eye drops and bifonazole ointment as models,
we compare the effects of xanthan gum, Arabic gum, and guar gum in
heterogeneous liquid and semi-solid preparations. The results show that the
thixotropic suspension and thickening properties of xanthan gum are better than
the other two gums, xanthan gum is an excellent suspending and thickening
agent.

In eye drops, the long contact time between the drug and the body can better
play the medicine effects. Xanthan gum is effective when it is used as an
auxiliary for eye drops, which can prevent and treat various ophthalmic
diseases such as retinitis and choroiditis. The rapid blinking of the eye makes
the viscosity of eye drops decrease, the drug quickly disperses and fully
contacts with the affected area. When the blinking is stopped, the viscosity
increases to make the eye drops difficult to flow and prolong the action time
of the drug. The eye drops which are prepared by mixing xanthan gum and sodium
hyaluronate can protect corneal epithelial cells and accelerate cell
regeneration.

Degradation and products

Xanthan gum oligosaccharides have the ability to scavenge hydroxyl free
radicals and activate the plant defense system to resist the infection of
pathogenic bacteria. At the same time, it also has antibacterial activity
against Xanthomonas campestris. Xanthan gum oligosaccharides also have strong
antiviral activity, plant inducing activity, and strong antioxidant activity.

Derivatives and applications

Xanthan gum derivatives have the characteristics of xanthan gum and other
substances, they have higher economic values. Among them, the graft
copolymerization method in chemical modification occupies an important position
in the production of derivatives. Xanthan gum also plays a certain role in the
immobilization and controlled release of antibiotic drugs. Xanthan gum is
mainly used as a slow-release agent and a controlled release agent for binder
disintegrants. When it is used as a binder, the tablet has strong adhesion and
it will not be too hard. At the same time, it can also add starch, gum arabic,
guar gum, locust bean gum, and other auxiliary materials to adjust to the
required hardness. During tablet compression and storage, splinters are not
easy to appear. This product has good swelling, wetting, and capillary action.
Therefore, it is also a good disintegrant. It is suitable for both highly
water-soluble drugs and poorly water-soluble drugs. At present, xanthan gum is
a component of microencapsulated drug capsules in the world and plays an
important role in controlling drug release.

Lipid-lowering drugs*

In terms of lipid-lowering drugs, xanthan gum and its compounds have suitable
viscosity and swelling coefficient which can prolong the gastric retention time
of food to reduce blood lipids. Attachment: Safety assessment of xanthan gum-In
1969, xanthan gum was approved by the U.S. Food and Drug Administration (FDA)
and was included in the National Formulary (NF) in 1975; In 1983, the United
Nations Food and Drug Administration and The World Health Organization
(FAO/WHO) approved and announced xanthan gum as a food additive at the Food
Additives Conference which was held in Rome. There are no restrictions on its
addition and no special regulations on allowable daily intake (ADI); In 1988,
approved by the Ministry of Health of China, xanthan gum was included in the
list of food additives. The "GB 2760-2014 Standard for the Use of Food
Additives" stipulated that xanthan gum can be used in various foods in
appropriate amounts according to production needs. In 2010, it is included in
the Chinese Pharmacopoeia (ChP) as a pharmaceutical excipient.

Because of the excellent physical and chemical properties, xanthan gum will
continue to attract the attention of scientific researchers at home and abroad.
As a pharmaceutical excipient, it will be widely used in the field of pharmacy,
more and better xanthan gum preparation will be developed. According to the
characteristics of xanthan gum, it has a great potentiality in the application
of the biomedical engineering field. The degradation products of xanthan gum
have a variety of biological activities. Deosen will continue to make
researches on the biological activity of xanthan gum degradation products and
look for more strains and enzymes that degrade xanthan gum to obtain more
degradation products under various conditions. The effective xanthan gum
products will be explored to meet the demands of domestic and international
xanthan gum markets.


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Minimum Order: 1 tons

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