Uthever® Cosmetic

β-Nicotinamide Mononucleotide（NMN）
CAS No. :1094-61-7
Product Name: Uthever® Cosmetic NMN (β-Nicotinamide Mononucleotide)
Newly Certified Cosmetic Ingredient 2023, with scientifically validated
skincare benefits.

1.7 Times Stronger Anti-Wrinkle Effe8ct
Whitening Effect
Prevent Skin UVB Damage
Moisturizing Effect
Skin repair
Antioxidant support

About Uthever® Cosmetics
β-Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3, which plays
a crucial role in human cell functions. NMN can be naturally produced in cells
or obtained through fruits, vegetables, and poultry. Research shows that NMN is
a bioactive compound that can boost cellular NAD+ levels. As we age, NAD+
levels in the body decline, so we need cellular health supplements.
Supplementing NAD+ can effectively slow down aging and improve the prevention
and management of age-related diseases.

Mechanisms of NMN
Increase NAD+ levels
Activate "longevity protein" sirtuins
Repair DNA damage
Promote energy production

Best NMN Power, Rising Potent Skincare Ingredient
NMN, short for β-Nicotinamide Mononucleotide, has been scientifically proven
to rapidly and effectively increase NAD+ levels in the body. The influence of
NMN now spread to the skincare field by targeting multiple pathways and
dimensions to maintain skin health.

Uthever®: Newly Certified Cosmetic Ingredient 2023
In February 2023, the China National Medical Products Administration approved
the application of Uthever® NMN as a cosmetic ingredient submitted by
EffePharm. Uthever® NMN can now be officially used as a cosmetic ingredient and
the finished product can be legally marketed and sold.

Enter the Uthever® Scientific Skincare Era
Uthever® NMN
As a clinical-backed NMN brand, Uthever® Cosmetics’ scientifically validated
skincare benefits include:
Repairing Skin Barrier
Human Efficacy Trials
Thirty-one healthy female subjects aged 18 to 60 years, all with dry skin, a
compromised skin barrier, and transepidermal water loss exceeding 15 g/m²/h,
continuously used Uthever® NMN at a concentration of 3% for 14 and 28 days. The
results indicated a reduction in transepidermal water loss of 26.23% and 37.60%
respectively, demonstrating that Uthever® NMN possesses significant
moisturizing properties.

Hydration Benefits
Human Efficacy Trials
Thirty-one healthy female subjects aged 18 to 60 years, all with dry skin, a
compromised skin barrier, and transepidermal water loss exceeding 15 g/m²/h,
continuously used Uthever® NMN at a concentration of 3% for 14 and 28 days. The
results showed that the hydration level of the stratum corneum increased by
32.44% and 54.66%, respectively, indicating that Uthever® NMN has a significant
repair effect.

1.7 Times Stronger Anti-Wrinkle Effect
In a controlled experiment targeting wrinkles, using Uthever® NMN at a
concentration of 0.625%, the increase in Type I collagen production was 70%
higher compared to Vitamin C and Vitamin E. It effectively activates the repair
of damaged cells, eliminates ageing cells, promotes the differentiation and
regeneration of healthy cells, and creates youthful, firm, and rejuvenated
skin.

Prevent Skin UVB Damage
Photodamage is a significant factor in skin aging, and by increasing
intermediate filament-related proteins like FLG and IVL, the skin barrier can
be fundamentally repaired. Research has found that NMN effectively enhances the
levels of FLG and IVL in the skin, repairing the stratum corneum and countering
photodamage caused by UVB exposure. This effect was further demonstrated in a
study using orally administered Uthever® NMN in mice.

Brighting Effect
As age increases, the number of free radicals rises, leading to reduced skin
vitality, loss of elasticity, formation of wrinkles, overall skin aging, dull
complexion, and formation of pigmentation. The experimental results in the
following figure demonstrate that Uthever® NMN can effectively eliminate free
radicals in the skin, restore firm and elastic skin, improve pigmentation, and
give the skin a more radiant glow.

Moisturizing Effect
AQP3 is one of the main indicators for measuring skin hydration. In experiments
focused on skin moisturization, immunofluorescence is used to track the
quantity of AQP3 (as indicated by IOD values in the image below). Uthever® NMN
has been proven to increase the number of skin AQP3 at different
concentrations, achieving deep hydration effects.

Minimum Order: 10 sets

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