SELL Metallothionein(MT)

INCI name: metallothionein, metallothioneins

Purity:70%,80%,95%

, Molecular:6500

Grade: cosmetic

Appearance:white powder

2.Functions:

Metallothionein( , MT) can eliminate free radicals and prevent aging; to lift
heavy metal toxicity; involved in the metabolism of trace elements in the
human body; enhance immune function and has the ability to adapt to a
variety of adverse state; prevent cancer cells; resistance to apoptosisand
so on.



3.Introduction:

Metallot , hionein (MT) is a family of cysteine-rich, low molecular weight (MW
ranging from 500 to 14000 Da) proteins. They are localized to the membrane
of the Golgi apparatus. MTs have the capacity to bind both physiological
(such as zinc, copper, selenium) and xenobiotic (such as cadmium, mercury,
silver, arsenic) heavy metals through the thiol group of its cysteine
residues, which represent nearly 30% of its constituent amino acid residues.

MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-
binding protein from horse (equine) renal cortex. MTs function is not clear,
but experimental data suggest MTs may provide protection against metal
toxicity, be involved in regulation of physiological metals (Zn and Cu) and
provide protection against oxidative stress. There are four main isoforms
expressed in humans (family 1, see chart below): MT1 (subtypes A, B, E, F,
G, H, L, M, X), MT2, MT3, MT4. In the human body, large quantities are
synthesised primarily in the liver and kidneys. Their production is
dependent on availability of the dietary minerals, as zinc, copper and
selenium, and the amino acids histidine and cysteine.

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