SELL Lipospondin

Name: Lipospondin
Formula: C21H35N5O4
Molecular:685
Sequence: N-Elaidoyl-KFK
Purity: ≧95%
Grade: cosmetic
Source: synthetic
Stability: stable
Appearance: white powder
MSDS and COA: available for your reference
Delivery: promptly from stock
2.Usage: prevent age-associated dermal alterations防止年龄相关的皮肤改变
3. , Description：N-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-
beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta,
and ex vivo using human dermal fibroblasts cultures. In both assays, as much
as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK,
KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-
mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1
production and down regulation of PMA-induced MMP-1 expression in
fibroblasts cultures. Those effects could be suppressed by supplementing
cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited
MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and
8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using
skin tissue sections, towards the elastin-degrading capacity of MMP-9 was
even more pronounced. At a 1 microM concentration, the lipopeptide decreased
by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be
considered as a promising model compound to prevent age-associated dermal
alterations.

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