Other Organic Chemicals

Levodopa is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. Levodopa is an immediate precursor of dopamine and product of tyrosine hydroxylase. It derived from vanillin is widely used for treatment of Parkinson’s disease, most often in combination with peripheral decarboxylase inhibitors such as benserazide and carbidopa. Brand: Soarwin CAS No.: 59-92-7 Molecular Formula: C9H11NO4 EC Number:200-445-2 Density: 1.3075 (rough estimate) Boiling point: 334.28°C (rough estimate) Melting point: 276-278 °C (lit.)

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L-carnitine is a naturally available compound that plays a significant role in fatty acid oxidation and energy production in the human body. It is majorly found in skeletal and cardiac muscles of mammals and facilitates the transport of long chain fatty acids into mitochondria. L-carnitine has been widely used in functional food as a new type of nutritional fortification agent, especially as an additive of infant formula food, athlete food and slimming and bodybuilding food. L-carnitine as a commodity is mainly its hydrochloride, tartrate and magnesium citrate. Brand: Soarwin CAS No.: 541-15-1 Molecular Formula: C7H15NO3 EC Number: 208-768-0 Density: 10.64 g/cm3 Boiling point: 287.5°C (rough estimate) Melting point: 197-212 °C(lit.)

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Monobenzone is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone is a topical decolorizing agent used to treat hyperpigmentation, such as various color spots, age spots, melanoma, etc., the effect is very obvious. It can decompose the melanin in the skin, prevent the generation of melanin in the skin, and restore the skin to a healthy color, without destroying the melanin cells, very light toxicity, usually made of ointment or liniment. Brand: Soarwin CAS No.: 103-16-2 Molecular Formula: C13H12O2 EC Number: 203-083-3 Density: 1.26 g/cm3 Boiling point: 297.96°C (rough estimate) Melting point: 119-120 °C (lit.)

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Pyrrolidinyl Diaminopyrimidine Oxide is a hair growth stimulant that can be used to treat hair loss. It can also be used in cosmetics to invent a dermocosmetic composition having a whitening or dark circle removal or anti- glare effect by containing a pyrrolidinyl diaminopyrimidine oxide compound as an active ingredient. Brand: Soarwin CAS No.: 55921-65-8 Molecular Formula: C8H13N5O EC Number: 618-347-7 Density: 1.60 Boiling point: 549.3±60.0 °C(Predicted)) Melting point: 278 °C (DEC.)

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Azelaic acid is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects. In vitro, azelaic acid hasbeen shown to inhibit DNA polymerases in several tumor cell lines. Application: A.Polymers and related materials: Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine azelaic acid forms Nylon - 6,9, which finds specialized uses as a plastic. B.Medical: Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne . It belongs to a class of medication called dicarboxylic acids. It works by killing acne bacteria that infect skin pores. It also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation . It clears the bumps and swelling caused by Rosacea. Azelaic acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyper pigmentation , particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone (HQ). As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin. Brand: Soarwin CAS No.: 123-99-9 Molecular Formula: C9H16O4 EC Number: 204-669-1 Density: 1.029 g/cm3 Boiling point: 286 °C100 mm Hg(lit.) Melting point: 98 °C Flash point: 215°C

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Thiamidol (also known as Isobutylamido Thiazolyl Resorcinol) is a patented and highly effective skin lightening ingredient developed by Beiersdorf, the parent company of Eucerin. It is designed to combat hyperpigmentation and reduce dark spots by targeting the root cause of melanin overproduction. Clinical studies have shown that Thiamidol can significantly reduce hyperpigmentation and dark spots on all skin types. For example, in a study on UVB-induced hyperpigmentation, Thiamidol-treated skin showed significantly less hyperpigmentation compared to untreated skin after UVB exposure. Additionally, improvements in skin tone were observed within as little as two weeks of regular use. Brand: Soarwin CAS No.: 1428450-95-6 Molecular Formula: C13H14N2O3S Density: 1.386±0.06 g/cm3(Predicted)

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Ginseng Extract (Panax sp.) is considered tonic and nourishing because of its vitamin and hormone content. It seems to aid in diminishing wrinkles and helps dry skin. It is also said to promote skin elasticity, perhaps by stimulating sterol and protein production. other claims include skin rejuvenating, oxygenating, and stimulating properties. Folkloric remedies cite use for boils, bruises, sores, and swellings. This root’s active components are called ginsenosides and these are said to be responsible for revitalizing and reactivating epidermal cells. other important constituents include saponins, mucin, and vitamin B. The extract comes from the root. ginseng has been associated with many allergic skin reactions. Despite the long popularity of ginseng and its evident mild stimulatory effect, there is less conclusive evidence for its clinical effectiveness than for many of the other herbs discussed in this chapter. In regard to improving cognitive function, most studies have failed to prove a consistent benefit. A recent investigation of ginseng’s effect on physical stamina found that an 8-week course of therapy failed to improve aerobic work capacity. Ginseng has been studied as a diabetic agent, with reduced hemoglobin A1c levels and improved glucose control being documented in a small trial. Although there is some intriguing work with ginseng as a cancer preventive, there is not enough evidence to suggest its clinical use at this time. Brand: Soarwin CAS No.: 90045-38-8 Molecular Formula:C15H24N2O EC Number: 289-898-5

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Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced. Cytidine 5'-Diphosphocholine is a single nucleotide composed of nucleic acid, cytosine, pyrophosphate and choline, which is mainly used in clinical treatment of a variety of neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis and so on. Studies have also shown that citicoline can increase the brain's uptake of dopamine and glutamate, thereby improving cognitive performance. It can also be used for metabolic disorders after craniocerebral trauma and brain surgery, consciousness disorders, paralysis tremor, neurological deafness and tinnitus, and sleeping pills poisoning. In addition, it also has a good effect on Parkinson's syndrome and cerebral thrombus paraplegia. Brand: Soarwin CAS No.: 987-78-0 Molecular Formula: C14H26N4O11P2 EC Number: 213-580-7 Melting point: >185°C (dec.)

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Quercetin is a pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine. It has a role as an antibacterial agent, an antioxidant, a protein kinase inhibitor, an antineoplastic agent, an EC 1.10.99.2 It can be used as a kind of antioxidant which is mainly used for oil, drinks, cold drinks, meat processing products. It has good effects of expectorant, anti-cough, anti-asthma and can be used for treating chronic bronchitis as well as for adjuvant therapy of coronary heart disease and high blood pressure. It can also be used as analytical standards. Brand: Soarwin CAS No.: 117-39-5 Molecular Formula:C15H10O7 EC Number: 204-187-1 Density: 1.3616 (rough estimate) Boiling point: 363.28°C (rough estimate) Melting point: 316.5 °C

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Berberine is the main active ingredient extracted from the rhizomes of Coptis, goldenseal family. It exists in the form of quaternary ammonium salt in nature, and its hydrochloride is commonly used in clinic. Berberine hydrochloride has many pharmacological effects such as anti-microbial, anti-arrhythmia, hypolipidemia, hypoglycemia, anti-inflammatory, anti-tumor, sedative and hypnotic. The product has antibacterial effect on hemolytic streptococcus, Staphylococcus aureus, gonococcus, Fredricki and Shigella dysenteriae, and has enhanced white blood cell phagocytosis, and has different degrees of inhibition effect on tuberculosis bacillus and plague bacterium. Widely used in the treatment of gastroenteritis, bacillary dysentery, tuberculosis, scarlet fever, acute tonsillitis and respiratory infections also have a certain effect. In traditional Chinese medicine, Coptis, Phellodendron, three needles and ten virtues are used as heat-clearing and detoxification drugs, among which berberine is the main active ingredient. Brand: Soarwin CAS No.: 2086-83-1 Molecular Formula: C20H18NO4 EC Number: 218-229-1 Density: 1.2976 (rough estimate) Boiling point: 486.8°C (rough estimate) Melting point: 204-206 °C (dec.)

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Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs. Mangiferin is a xanthonoid, a chemical compound found in mangoes and in Anemarrhena asphodeloides rhizomes. Mangiferin has effect of hepatinica and choleretic, and is used to therapy hepatitis. Mangiferin is an anti- inflammatory, antivirotic, central nervous system inhibit function and immunologic suppression. Mangiferin has curative effect on chronic bronchitis. Mangiferin has cytotoxicity effect on hepatocellularcarcinoma ce1l, and may induce apoptosis. Mangiferin has the effect of antioxidation and delaying caducity. Brand: Soarwin CAS No.: 4773-96-0 Molecular Formula: C19H18O11 EC Number: 624-757-7 Density: 1.843±0.06 g/cm3(Predicted) Boiling point: 842.7±65.0 °C(Predicted) Melting point: 269-270°C

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Arbutin is a β-D-glucopyranoside HQ derivative and a plant-derived compound found in the dried leaves of several plant species, including blueberry, cranberry, bearberry, and pear trees. It suppresses tyrosinase activity without altering RNA expression. Arbutin is used primarily for its anti-oxidant and bleaching properties. Arbutin is the active constituent of bearberry, and found in other plant sources, including wheat. It acts as a tyrosinase inhibitor by converting to hydroquinone, and thus can prevent melanin formation. Arbutin is a glycosylated hydroquinone extracted from bearberry plant. Arbutin is a known inhibitor of tyrosinase, which in turn prevents the formation of melanin. Arbutin is often used as a skin-ligh tening agent in cosmetic products. Brand: Soarwin CAS No.: 497-76-7 Molecular Formula: C12H16O7 EC Number: 207-850-3 Density: 1.3582 (rough estimate) Boiling point: 375.31°C (rough estimate) Melting point: 195-198 °C Flash point: 293.4°C

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Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. It is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Brand: Soarwin CAS No.: 458-37-7 EC Number: 207-280-5 Molecular Formula:C21H20O6 Density: 0.93 Boiling point: 418.73°C (rough estimate) Melting point: 183 °C Flash point: 208.9±23.6 °C

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Fisetin, a well-known plant flavonol from natural flavonoid group, is found in traditional medicines, plants, vegetables, fruits. Fisetin also has anti- oxidant, anti-inflammatory, anti-tumor effects. Fisetin is primarily used in laboratory bioactivity studies as an analytical standard for qualitative and quantitative analyses of Fisetin, and as a dietary supplement, and sells well for its potential anti-aging and cognitive enhancing effects. Because of its potent antioxidant and anti-inflammatory properties, it has been shown to have varying degrees of inhibitory effects on a wide range of diseases (e.g., cancer, Alzheimer's disease, anti-aging cells, and diabetes), and has been extensively studied in terms of its pharmacological effects in vitro and in vivo. Brand: Soarwin CAS No.: 528-48-3 EC Number: 208-434-4 Molecular Formula:C15H10O6 Density: 1.2981 (rough estimate) Boiling point: 348.61°C (rough estimate) Melting point: >330 °C(lit.)

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