Other Organic Chemicals

a.Organic synthesis: Long chain fatty ketone is important intermediates in the synthesis of other organic compounds and can be used to prepare a variety of chemicals. b.Biomarkers: In geological and paleoenvironmental studies, long-chain fatty ketones (such as long-chain enones) are used as biomarkers to reconstruct paleoclimate and paleoenvironment. c.Industrial applications: Long chain fatty ketones also have certain applications in the fields of fragrances, pharmaceuticals and materials science Brand: Soarwin

Long-Chain Fatty Alcohol is used in the manufacture of detergents, emulsifiers, antistatic agents and plasticizers. Brand: Soarwin Molecular Formula: CnH2n+1OH

DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers. Brand: Soarwin CAS No.: 104872-42-6 Molecular Formula: C42H84ClNO2

a.Bioluminescence Imaging (BLI): In vivo tracking of tumors, infections, or gene expression (e.g., luciferase reporter assays). Preferred for D-luciferase mutants over traditional L- luciferin. B.Drug Discovery: High-throughput screening (HTS) for compounds affecting luciferase-coupled pathways (e.g., NF-κB, HIF-1α). C.Metabolic Studies: ATP-dependent light emission correlates with cellular metabolic activity. Brand: Soarwin CAS No.: 768593-01-7 EC Number: 616-121-2 Molecular Formula: C13H7FNNa2O3S2

Fluorescent labeling and imaging: live/stationary cell labeling (e.g. cell membrane, intracellular targets); Confocal microscopy, fluorescence microscopy imaging. Molecular probes: conjugation of antibodies, nucleic acids (such as FISH probes), nanoparticles for immunofluorescence, in situ hybridization, etc. Biosensing: Fluorescent sensors are designed to detect changes in enzyme activity (e.g., esterase, phosphatase), reactive oxygen species (ROS), or pH. Flow cytometry: Labeling of cell surface antigens or intracellular proteins for high-throughput screening. Brand: Soarwin CAS No.: 74638-76-9 EC Number: 616-121-2 Molecular Formula: C11H7FN2O3S2 Density: 1.89±0.1 g/cm3(Predicted) Boiling point: 570.0±60.0 °C(Predicted)

D-Luciferin potassium salt(115144-35-9) is a water soluble form of D-Luciferin. D-Luciferin is a common bioluminescent substrate used for imaging of firefly luciferase expression with peak chemiluminescent emission at 560 nm. The ATP dependant luciferin oxidation is catalyzed by the Luciferase enzyme encoded by lucgene. D-Luciferin may be used as a substrate in luciferase-based (EC 1.13.12.7) bioluminescence imaging and cell-based high-throughput screening applications. ATP can be measured with a reagent made up of D-luciferin and luciferase from firefly. D-Luciferin may be used and studied as a partial agonist for G protein-coupled receptor-35 (GPR35). Used for imaging the expression of the LUC marker gene and luciferase-fusion conjugates in living cells, tissues and organisms. Extensively utilized in reporter gene assays, immunoassays and hygiene monitoring. Brand: Soarwin CAS No.: 115144-35-9 EC Number:1592732-453-0 Molecular Formula: C11H9KN2O3S20

D-Luciferin is a chemiluminescent substrate of firefly luciferase. It produces light upon oxidative decarboxylation by luciferase in the presence of ATP. D- luciferin can be employed to assay the expression of the luciferase gene linked to a promoter of interest. Alternatively, D-luciferin and luciferase can be used to assess ATP availability in cellular or biochemical assays. D-lucifcein can be used as an indicator to identify the source of groundwater, determine the approximate volume of water flowing from cracks, find drinking water pollution sources, study the infiltration of industrial wastewater into the soil, and as an indicator of corneal trauma. Brand: Soarwin CAS No.: 103404-75-7 EC Number: 600-430-4 Molecular Formula: C11H9N2NaO3S2

Kopexil is a valuable organic synthetic reagent for preparing pyrimidines and in making hair loss and skin care compositions. It is used in hair care formulations to prevent increased hair loss. Brand: Soarwin CAS No.: 74638-76-9 EC Number: 616-121-2 Molecular Formula: C4H6N4O Density: 1.69±0.1 g/cm3(Predicted) Boiling point: 475.5±37.0 °C(Predicted)

Kopyrrol is a hair growth stimulant that can be used to treat hair loss. It can also be used in cosmetics to invent a dermocosmetic composition having a whitening or dark circle removal or anti-glare effect by containing a pyrrolidinyl diaminopyrimidine oxide compound as an active ingredient. Brand: Soarwin CAS No.:55921-65-8 EC Number: 618-347-7 Molecular Formula:C8H13N5O Density: 1.60 Boiling point: 549.3±60.0 °C(Predicted) Melting point:278°C(DEC.)

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock. Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension. Brand: Soarwin CAS No.:38304-91-5 EC Number: 253-874-2 Molecular Formula: C9H15N5O Density: 1.1651 (rough estimate) Boiling point: 348.61°C (rough estimate) Melting point:272-274 °C (dec.) (lit.)

Crisaborole is a member of the class of benzoxaboroles that is 5-hydroxy-1,3- dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release.5-(4-Cyanophenoxy)-2,3- dihydro-1-hydro , xy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent. The biggest advantage of Crisaborole is that it isa small molecule, non-hormonal drug, which can achieve both therapeutic efficacy and comfort, and even few side effects in some patients. It is the first non-dermatologic drug to enter the list of clinically urgent new drugs. Its listing fills the treatment needs of children and adults with atopic dermatitis in China, breaking the status quo of no new products in the field of topical non-hormonal anti-inflammatory for more than 10 years, and has epoch-making significance. Brand: Soarwin CAS No.:906673-24-3 EC Number: 250-635-4 Molecular Formula:C14H10BNO3 Density: 1.33±0.1 g/cm3(Predicted) Boiling point: 425.9±55.0 °C(Predicted) Melting point: >130 °C (softened)

Tapinarof is a small molecule stilbene compound, with a chemical name of 3,5- Dihydroxy-4-isopropylstilbene,which was originally isolated from the metabolite of photorhabdus iuminescence, a soil nematode (Heterorhabditis sp.), and has been synthesized artificially. Clinically, tapinarof was first used in the treatment of psoriasis and atopic dermatitis. Clinical trials conducted abroad have shown that Benzenemod cream has good efficacy and safety on atopic dermatitis and psoriasis. Tapinarof is a novel small molecule topical therapeutic AhR ( aryl hydrocarbon receptor)- modulating agent that has been recently approved by the FDA for the topical treatment of plaque psoriasis in adults. Tapinarof 1% cream has shown to be effective and to have a favorable safety profile in the treatment of psoriatic patients. It could decrease the expression of multiple essential cytokines involved in the pathological IL-23/IL-17/IL-22 axis and ameliorate IMQ-induced psoriatic dermatitis, inhibiting keratinocyte proliferation and abnormal differentiation. Brand: Soarwin CAS No.:79338-84-4 EC Number: 1312995-182-4 Molecular Formula:C17H18O2 Density: 1.158 Boiling point: 431.8±20.0 °C(Predicted) Melting point: 140 - 142°C

2,4,6-Trimethylbenzoyl chloride is an important organic reagent that can be used for the electrochemical reduction reaction to prepare 2,4,6- trimethylbenzaldehyde and tetramer (i.e. 1,2-bis(2,4,6- trimethylphenyl)ethylene-1,2-dio , l bis(2,4,6-trimethylbenzoate)). 2,4,6-Trimethylb , enzoyl chloride is used, in the presence of pyridine, to protect OH groups as mesitoate esters. Brand: Soarwin CAS No.: 938-18-1 EC Number: 213-339-6 Molecular Formula: C10H11ClO Density: 1.095 g/mL at 25 °C Boiling point: 143-146 °C (60 mmHg) Flash point: 143-146 °C/60mm

1,3-Dibromopropane is a dihalogenated propane. It is a colourless to slightly yellow liquid with sweet odor. soluble in ether, acetone and chloroform, insoluble in water. Decomposes when exposed to heat for a long time and is partially converted to 1,2-dibromopropane. Boiling with water produces propylene glycol. It is used substrate specificity of haloalkane dehalogenases. It undergoes reduction catalyzed by electrogenerated solution-phase nickel(I) salen and nickel(I) salen confined in a polymer film on the surface of a carbon electrode to afford cyclopropane and propylene, respectively. 1,3-Dibromopropane is used to prepare C3-bridged compounds through C-N coupling reactions. It is used in the preparation of 2,3,4,5-tetrahydro-7,7- diphenylimidazo- [2,1-b]-thiazine-6(7H)-one by reacting with potassium salt of 5,5-diphenyl-2-thiohydantoin. Brand: Soarwin CAS No.: 109-64-8 EC Number: 203-690-3 Molecular Formula: C3H6Br2 Density: 1.989 g/mL at 25 °C (lit.) Boiling point: 167 °C (lit.) Melting point: -34 °C (lit.) Flash point: 54°C