Organic Chemicals

Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements. Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside was originally identified as a nutrient in milk and later discovered to be a NAD(+) precursor. Nicotinamide riboside (NR) is a naturally occurring vitamin B-3 present in the human diet that acts as an NAD+ precursor and is suggested to improve mitochondrial function and insulin sensitivity. NR acts via activation of the NAD+-dependent sirtuin enzyme family, thereby regulating oxidative metabolism. In vitro experiments of NR supplementation have shown its successful NAD+-restoring capability and subsequent increased oxidative gene expression in skeletal muscle cells. Results from in vivo mouse models have shown improvements in insulin sensitivity and oxidative energy metabolism, including enhanced metabolic flexibility, increased aerobic exercise capacity, and indications of improved mitochondrial biogenesis. Brand: Soarwin CAS No.: 23111-00-4 Molecular Formula: C11H15ClN2O5 EC Number: 200-184-4

Used as acid, chelating agent, antioxidant enhancer, flavoring agent, quick- acting leavening agent, acidic substance, edible pigment diluent. Curing agent: Generally, 0.1% - 0.2% is added to cool beverages, and it is often used in combination with other organic acids such as citric acid and malic acid. In sweet food products, the limit is 2% in Japan and 4% in the United States. Brand: Soarwin CAS No.: 87-69-4 EC Number: 201-766-0 Molecular Formula: C4H6O6 Density: 1.76 Boiling point: 170-172°C(lit.) Melting point: 399.3oC at 760 mmHg Flash point: 210 °C

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1,4-Cyclohexanedicarboxylic Dimethyl Ester is a building block that has been used as a reactant for the preparation of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase. Brand: Soarwin CAS No.: 94-60-0 EC Number: 202-347-5 Molecular Formula: C10H16O4 Density: 1.111 g/mL at 25 °C Boiling point: 24-27 °C Melting point: 132 °C10 mm Hg(lit.) Flash point: 94°C

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β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+. β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra. β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels. Brand: Soarwin CAS No.: 1094-61-7 Molecular Formula: C11H15N2O8P EC Number: 214-136-5 Melting point: 166 °C(dec.)

Pyrroloquinoline quinone disodium salt is a water-soluble quinone compound that has a strong antioxidant capacity. It is isolated from cultures of methylotrophic bacteria and tissues of mammals. This essential nutrient is vital for mammals, playing a crucial role in enhancing immune function. Pyrroloquinoline quinone disodium salt can act as an antioxidant and there is strong evidence that PQQ may play an important role in important pathways of cell signaling. PQQ plays a variety of physiological roles, such as promoting growth and reproduction and providing neurological and cardiovascular protection. Pyrroloquinoline quinone disodium salt protects cells from oxidative damage and increases the mitochondrial membrane potential, which is essential for the production of ATP. It also stimulates enzyme activities, such as glutathione peroxidase and glutathione reductase, and prevents lipid peroxidation of human serum. This compound also inhibits radiation-induced cellular damage by preventing DNA strand breakage. It may be effective in treating diseases related to oxidative stress, such as diabetes and cancer. Brand: Soarwin CAS No.:122628-50-6 Molecular Formular:C14H4N2Na2O8 EC Numbe: 209-118-9 Boiling point: 1018.6°C at 760 mmHg Flash point: 569.8°C

D(-)-Salicin is a traditional medicine which has been known to exhibit anti- inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models. D-(-)-Salicin has been used:to study its in vitro anticoagulant and antiplatelet activities; as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant; as a tastant in taste threshold assay; as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei. Brand: Soarwin CAS No.:138-52-3 Molecular Formular: C13H18O7 EC Numbe: 205-331-6 Density: 1.4340 Boiling point: 388.65°C (rough estimate) Melting point:196-202 °C

Oat Beta Glucan is a water-soluble dietary fiber extracted from oats. Oat Beta Glucan lowers cholesterol levels by increasing the viscosity of the digestive contents. It binds to bile acids in the digestive tract, preventing their reabsorption in the ileum and increasing their excretion. This forces the body to use more cholesterol to produce new bile acids, thereby reducing blood levels of low-density lipoprotein cholesterol (LDL-C). Oat Beta Glucan is a versatile, natural ingredient with multiple health benefits, including cholesterol reduction, blood sugar regulation, gut health improvement, immune enhancement, and skin health promotion. Its widespread use in food, health supplements, and cosmetics makes it an important functional ingredient. Brand: Soarwin

3-Hydroxybutanoic acid calcium salt is used as a nutritional supplement that can increase blood ketone levels, improve athletes' endurance, mental performance and energy levels. Brand: Soarwin CAS No.:586976-56-9 Molecular Formular:C4H10CaO3

Palmitoylethanolamide (PEA) is a fatty acid amide produced in the body that binds to and activates the peroxisome proliferator-activated receptor alpha (PPAR-α). It was initially described as an agonist to the type 2 cannabinoid receptor (CB2), though it is now recognized that PEA does not bind to cannabinoid receptors. PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain. Palmitoylethanolamide is a natural substance produced by the body and it is very effective and safe to use as a supplement for pain and reduce inflammation. PEA can be synthesized within the human body from the abundant fatty acid palmitic acid, but it is not dependent or influenced by dietary consumption of fatty acids. Palmitic acid in the diet is derived from dairy products such as cheese and butter, palm tree oil, and animal meat products. However, increasing palmitic acid in the hope of increasing endogenous PEA synthesis will not be effective. The anti-inflammatory properties of PEA are due to its ability to inhibit inflammation-causing proteins called cytokines. Cytokines are released during periods of inflammation. PEA can suppress the secretion of tumor necrosis factor alpha (TNF alpha), a cytokine, while also inhibiting the release of interleukins. Brand: Soarwin CAS No.:544-31-0 Molecular Formular:C18H37NO2 EC Numbe: 208-867-9 Density: 0.910±0.06 g/cm3(Predicted) Boiling point: 461.5±28.0 °C(Predicted) Melting point: 97-98°C

Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates. Brand: Soarwin CAS No.:5471-51-2 EC Number: 226-806-4 Molecular Formula: C10H12O2 Density: 1.0326 (rough estimate) Boiling point: 200°C Melting point: 81-85 °C (lit.) Flash point: 122.9°C

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock. Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension. Brand: Soarwin CAS No.:38304-91-5 EC Number: 253-874-2 Molecular Formula: C9H15N5O Density: 1.1651 (rough estimate) Boiling point: 348.61°C (rough estimate) Melting point:272-274 °C (dec.) (lit.)

chiral nematic liquid crystals CE9 94442-17-8 CE9 4-((2s)-2-methylbutyl)phenyl-4-propylbenzoate 94442-17-8 Established in 2007, Qingdao QY Liquid Crystal Co., Ltd is a leading manufacturer specializing in high-quality nematic liquid crystals, primarily used in PDLC smart film and high grade of LC display. With over 18 years of nematic liquid crystals production expertise. Our LCs are widely exported to Europe, the United States, South Korea, and other global markets. The capable of our producing approximately 5000 kilograms per month. We signed the Exclusive Agency Agreement with our South Korean customer from 2011

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2,4-Diamino pyrimidine-3-oxide is a valuable organic synthetic reagent for preparing pyrimidines and in making hair loss and skin care compositions. It is used in hair care formulations to prevent increased hair loss. Brand: Soarwin CAS No.: 74638-76-9 Molecular Formula: C4H6N4O EC Number: 616-121-2 Density: 1.69±0.1 g/cm3(Predicted) Boiling point: 475.5±37.0 °C(Predicted) Flash point: 241.374°C

Silymarin is a kind of flavonoid complex consisting of silybin, silydianin, and silychrisin, derived from the milk thistle plant. It is a kind of potent antioxidant, anti-cancer agent as well as liver protecting agent. It has a lot of pharmaceutical functions. For example: (1) Promotes healthy liver function and general health; (2) Strengthen the normal cellular defense system to protect the liver tissue; (3) Help to eliminate the toxin accumulating in the liver; (4) Increase the survival rate of patients of cirrhosis; (5) Protect our body against industrial poisons; (6) Antidote against the death cap mushroom. Silymarin exerts its pharmaceutical effects through various mechanism including scavenging free radicals, increasing glutathione (has detoxifying effect) level in the liver, increasing the levels of antioxidant enzymes such as superoxide dismutase, stimulating liver protein synthesis and inhibiting the synthesis of leukotrienes. Brand: Soarwin CAS No.: 65666-07-1 Molecular Formula: C25H22O10 EC Number: 613-830-9 Density: 1.527±0.06 g/cm3(Predicted) Boiling point: 793.0±60.0 °C(Predicted) Melting point: 158 °C Flash point: 274.4°C