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Innovative design of RNase-free bioprocess disposable bags with 100% RNase/DNase inspection and release of products and customer verification. Features of NovaLinX RNase Free Single-use rnase free bag Master bag + Innovative design of double satellite bags (enabling RNase-/DNase- free bags 100% individual inspection). Identical material/production environment of master bag and satellite bag. Satellite bag -1 (QC Release) For RNase inspection prior to product release. Satellite bag -2 (Customer Verification) For customer verification test before/after use. Different sizes/models of disposable bioprocess bags (Mixing bags + Bioreactor bags +cellbag, etc.). High standard production environment control and monthly RNase monitoring. Why choose rnase free container？ Novalinx Rnase Free Disposable Consumable mRNA, a new generation technology platform that is expected to change traditional ways of vaccines and monoclonal antibodies development and manufacturing. Due to its short R&D cycle, simple production process, strong immunogenicity and high safety, mRNA has the potential to be widely applied in various fields such as vaccines for infectious diseases, tumor immunology and recombinant protein. Ribonucleases (RNase), a class of nucleic acid hydrolases that are widely found in animals and plants. Due to its "ubiquitous" nature, it is necessary to take multiple and complex clean-ups to eliminate the effects of RNase in the mRNA production process, which greatly reduces the production efficiency. Meanwhile, the process validation and verification of RNase removal are also timeconsuming and labor-intensive. Therefore, RNase-Free disposable consumables are highly welcomed by mRNA manufacturers using single-use bioprocess technology for production. In addition, RNase level within those consumables shall be inspected before release and can be verified post-use without damage. As a leading supplier of bioprocessing products, Bio-Link has launched an innovative design of RNAse-inhibiting bags for the first time with 100% RNase/DNase inspection and release of products and customer verification. The company has been working with biopharmaceutical companies to accelerate the application of disposable biotechnology products in mRNA R&D and production. For more information about biolink solutions, please feel free to contact us!

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Electrokinetic axial compression large chromatography column is the most commonly used and even necessary method for the separation and purification of biological macromolecules in drug development and mass production. LK-Auto series tomographic columns are easy to install, simple to use, safe and reliable. Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding. Features of large scale chromatography column • Column tube is acrylic structure, clear vision, column bed position visible; • Sanitary design, in line with GMP requirements; • Material safety, in line with the regulatory requirements; • Scientific design, no clean dead corner; • Can be used for a variety of packing; Specifications of inner diameter: 300,450,600,800,1000,1200 mm • Height range: 550 and 570 mm • Screen aperture: 10μm and 20μm are optional As a professional lifescience company, BioLink is committed to continuously providing customers with high-quality innovative products and solutions.

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In the downstream separation and purification process of biopharmaceuticals, chromatography is one of the indispensable separation methods. Bio-Link provides customers with 5 different chromatography solutions, including gel filtration chromatography, ion exchange chromatography, affinity chromatography , hydrophobic chromatography and multimodal chromatography. In addition, Bio- Link also produces chromatography columns and prepacked columns from laboratory to industrial grade. We focus on providing customers with high-quality products, professional solutions and comprehensive after-sales services. How To Select The Appropriate Chromatography Resin For My Own Process? To select a suitable chromatography medium and chromatography mode, we need to clarify the purpose of chromatography and the isoelectric point PI (charge property) of the target product. The PI of the target product can be obtained by calculating the target product sequence (theoretical isoelectric point), or by capillary isoelectric focusing electrophoresis (CIEF) (actual isoelectric point). Separation of substances based on the difference in charge between the target product and impurities in a buffer with a specific pH value. According to different chromatographic purposes, two modes can be selected for the ion exchange chromatography process: (1) flow-through mode: the target product does not bind to the packing material, and impurities are bound to the chromatography packing material as much as possible; (2) combined elution mode : The target product is combined with the filler, and then eluted with a certain concentration of salt. FAQs of Ion Exchange Chromatography  What is the principle of ion-exchange chromatography?  resin column chromatography is a chromatography method that separates substances according to the difference in charge properties of different biomolecules. The ion exchange chromatography medium is composed of agarose/dextran/polymer matrix coupled with ligands with positive and negative charges. The medium with negative charge is called cation exchange chromatography medium, which can bind positively charged proteins; the medium with negative charge is called anion exchange chromatography medium, which can bind negatively charged proteins.  How many chromatography resin can Bio-Link produce per year?  The chromatographic medium manufacturing facility for Bio-Link is situated in Lanzhou City, Gansu Province, and spans a total area of more than 7,000 square meters. The factory is in charge of producing purification and cell culture items such chromatography packing materials and microcarriers, with a total investment of more than 100 million yuan and close to 100 workers. The base now contains a production line for 500L and 1000L chromatography packaging, as well as a well-equipped laboratory for quality testing (which has earned ISO9001:2015 quality management system accreditation). The plant's 80,000 liters per year total capacity is envisaged. As a professional lifescience company, BioLink is committed to continuously providing customers with high-quality innovative products and solutions.

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Column chromatography is a very common separation and purification method in drug development and mass production. It is widely used in various separation and purification steps. To meet the purification needs of our biopharmaceutical customers, we have designed the BLK-BP series of columns for common biopharmaceutical tomographic applications. The column is easy to install, simple to use, safe and reliable. Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding. Features of Industrial Chromatography Column • The tube is made of glass, and the field of view is clear. It is convenient to observe the position of the bed (the bed height can be determined by comparing with the scale line on the outer wall of the tube) and the state of the glue surface. • Sanitary design, in line with GMP requirements; • Can manually adjust the height of the cylinder head and lock the sealing ring by rotating screw, easy to operate; • Easy maintenance and repair; • The side outlet is reserved at the bottom to facilitate the connection of valves and pipelines; • Level screw handle meets ergonomic requirements, easy to operate. • Optional diameter specifications: 100, 200, 300, 450 mm; • Optional height specifications: 500, 750, 950 mm; • Optional screen aperture: 10μm, 20μm As a professional lifescience company, BioLink is committed to continuously providing customers with high-quality innovative products and solutions.

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Chrom-LinX® large glass chromatography columns can be divided into two designs: single and double adjustable cylinder. The single adjustable cylinder design mainly consists of adjustable cylinder, column tube and fixed cylinder. The double adjustable cylinder design replaces the fixed cylinder with an adjustable cylinder to extend the volume range that can be loaded. Chrom-LinX® laboratory grade chromatographic column is standard with 10 μm screen (optional 5 μm screen) and is compatible with common tomographic fillers of different particle sizes. Chrom-LinX® laboratory grade chromatographic columns are made of biocompatible materials with good chemical tolerance. It is compatible with common aqueous solutions and most organic solvents, but does not tolerate chlorinated hydrocarbons, acetone and other ketones, fatty esters and phenol, etc. At the same time, it is prohibited to use under the condition of containing more than 2 M NaOH, 1 M HCl, other strong inorganic acids, 75% acetic acid solution. Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding. Features and Benefits of Chrom-LinX Laboratory Grade Empty Columns User-friendly design: Ergonomically design the components for easy grasping and handling. Clear view: Equipped with a measurement scale of glass tube for easy to predict and reach a predefined bed height and improving process reproducibility. High pressure resistance: compatible with common resins of different particle sizes allowing operation up to 20 bar* (2 MPa, 290 psi) pressure. Various sizes: Glass tubes with inner diameter (i.d.) of 10 mm, 16 mm, 26 mm or 50 mm, and bed height of 200 mm, 400 mm, 700 mm or 1000 mm provide a wide range of column volumes. High flexibility: Equipped with single/double adjustable capital for flexible expansion of column volumes. Easy to clean: Each component for easy assembling removing and cleaning. Compatibility: Supplied with tubing and connectors suitabling for a variety of common laboratory tomographic systems. *The columns withstands pressures up to 7 bar (0.7 MPa, 101.5 psi) with 50 mm inner diameter. Product Characteristics of Chrom-LinX Laboratory Grade Empty Columns Chrom-LinX® laboratory grade empty chromatography column are divided into two designs: single adjustable capital and double adjustable capital. The design of single adjustable capital mainly consists of an adjustable capital, a chromatography column tube and a fixed capital. The design of double adjustable capital replaces the fixed capital with an adjustable capital to extend the column volume (Fig 2). Chrom-LinX® laboratory grade empty chromatography columns is standard equipped with 10 μm net ring (5 μm net ring being also optional), which is compatible with common resins of different particle sizes. Chemical Resistance of Chrom-LinX Laboratory Grade Empty Columns Chrom-LinX® laboratory grade chromatography columns empty are made of biocompatible materials with good chemical tolerance. The columns can be used in aqueous solutions and almost all the organic solvents commonly used in liquid chromatography of macromolecules. The columns intolerant of chlorinated hydrocarbons, acetone and other ketones, aliphatic esters, and phenol. The columns are not allowed to use the solution containing more than 2 M NaOH, 1 M HCl, other strong mineral acids, or 75% acetic acid.

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CytoLinX® WB series single-use cell culture bags are suitable for wavy cell culture systems and are designed for common wave bags cell culture applications in biopharmaceuticals. Can be used for scientific research, process development, commercial production operation. This product is irradiation sterilization product, disposable use, for cell growth to provide a safe and suitable environment. Available in a range of sizes to support cultures from 25ml to 25L. Includes basic cell culture bag, pH&DO cell culture bag, perfusion cell culture bag, pH&DO perfusion cell culture bag. Features of CytoLinx WB Cell Culture Bags Cell Culture Media Bags • Simple installation and easy operation; • Minimize the risk of contamination and cross-contamination between samples; • Good stability, the bag is composed of multiple layers of co-extruded transparent film, excellent mechanical strength, suitable for a long time cell culture process; • High cell density; • Good biological safety, material liquid contact layer is EVA copolymer, biological inert material, to ensure process safety; • Complete verification documents; • Reduce costs; • Can be used from 10° C to 50° C; • Maximum operating pressure: 0.1 bar; • Flexible customization of pipes, joints and other components according to customer requirements; Permalife Cell Culture Bags Specifications of CytoLinX WB Cell Culture Bags CytoLinX™ WB Cell Culture Bag Components CytoLinX™ WB cell bags are made of multi-layer co-extruded film materials, the material-liquid contact layer is EVA copolymer, which is widely used in the field of biopharmaceuticals, and the outer layer is a composite material with good flexibility, strength and very low gas permeability, suitable for common cell system culture. Verify file overwriting: Aseptic test. Endotoxicity test. Completeness test. Extractable test. Chemical compatibility table. Tested on a gamma-irradiated bag, biocompatibility complies with: 1) ISO 10993-4: In vivo hemolysis study (extraction method). 2) USP87: Cytotoxicity study (extraction method). 3) USP<88> Class VI muscle implant test. 4) USP88: Study on acute intradermal injection reaction. 5)USP88: Acute systemic toxicity study. As a professional lifescience company, BioLink is committed to continuously providing customers with high-quality innovative products and solutions.

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