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PDO Thread Lift is the latest and revolutionary treatment for skin tightening and lifting as well as Vshaping the face. These threads are made of PDO (polydioxanone) material which is similar to the threads used in surgical stitches. PDO material is used for more than 30 years in plastic surgery, gastroenterology, urology, gynaecology, ophthalmology for cutaneous and subcutaneous stitches. These threads have high tensile strength, excellent pliability and smooth tissue passage. This material meets all the requirements established by the United States Pharmacopeia (USP) for surgical sutures. PDO ultimately breaks down into water and carbon dioxide which are naturally absorbed into skin. PDO cause a very mild reaction during absorption, minimal acute inflammatory reaction with subsequent formation of new collagen production around the thread .

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What is glabridin? Glabridin, also known as Glycyrrhizic Flavone, is an kind of isoflavone. It is extracted from the dried rhizome of Glycyrrhiza glabra L. Glabridin is one of the main flavonoids in Glycyrrhiza glabra (accounting for 11%). Numerous studies have shown that Glabridin can effectively inhibit the activity of various enzymes during melanin production, especially inhibiting tyrosinase activity. Moreover, it has other skin-care effect such as anti- inflammation, anti-oxidation and sun-protection. It is a safe, mild and effective whitening active ingredient. Only 100g Glabridin can be extracted from 1000kg Glycyrrhiza glabra. Because of its complicated extraction process, high cost and price, it is comparable to gold price. Therefore, it is known as " Whitening Gold" in the world cosmetics industry. Glabridin has attracted much attention and is widely used in skin beauty products and cosmetics. Product Name Glabridin Part Used Root Latin Name Glycyrrhiza uralensis Fisch Extract Solvent Water&Ethanol Appearance Light brown powder (White Powder for 90% 98%) Assay(HPLC) ≥40% 90% 98% Product Name Specification Color Glabridin 98% HPLC White powder 90% HPLC White powder 40% HPLC White powder 40% HPLC Brown powder Function: Skin whitening as a natural whitening ingredient, the skin-whitening mechanism of Glabridin mainly includes: (1) inhibiting tyrosinase activity; (2) inhibiting the activity of dopachrome tautomerase (TRP-2) (3) inhibiting the activity of DHICA oxidase; (4) exerting the function of endothelin antagonist; (5) increasing the total antioxidant capacity of the skin; (6) effectively scavenging oxygen free radicals and its chain reaction. Moreover, through these synergistic effects, it effectively prevents the polymerization of 5,6-dihydroxyindole (DHI) and the production ofdopachrome. Thereby Glabridin can disturb and hinder the formation and transport of melanin; and then it inhibits and reduces pigmentation so as to achieve whitening skin effect. Anti-inflammatory and antibacterial the anti-inflammatory effect of Glabridin is related to its anti-oxidative activity of scavenging reactive oxygen. Glabridin can inhibit the production of NO in macrophages and the expression of inducible NO synthase. Then it can prevent the development of inflammation. Also Glabridin can inhibit the activity of staphylococcus aureus and candida albicans. It has a strong antibacterial effect, and can be used for the treatment of acne. Antioxidant Glabridin has shown strong anti-free radical oxidation in the cytochrome oxidation system. It can significantly inhibit the free radicals generated in the body's metabolism. Then it prevents the oxidation-sensitive bio- macromolecules (LDL, LDL, DNA) and cell walls from being oxidized and damaged by free radicals. As an antioxidant, Glabridin can also inhibit the production of reactive Oxygen species and activation of p53; it regulates the cleavage of BCL-2 and poly ADP ribose polymerase. and it can fight against oxygenated DNA fragments of keratinocytes induced by UV; then it prevents sun-induced skin aging. Sunscreen the conjugate property in the molecular structure of licorice flavonoids assures that Glabridin is characterized by strong Absorption of both ultraviolet and visible light. Therefore, the sunscreen mechanism of Glabridin has the highest absorption peak for ultraviolet rays. and it effectively blocks ultraviolet rays from the skin surface after being applied to the skin. Furthermore, it also works by absorbing unstable molecules of high-energy ultraviolet rays. Then it converts the ultraviolet rays that damage the skin into harmless, low-energy and non-damaging ones. Application: Skin care products: ointment, cream, lotion, facial mask Bath products: shower gel Hair care products: Shampoo, hair mask Sunscreen products

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