Cosmetic & Hair Care Chemicals

Name: Lipospondin Formula: C21H35N5O4 Molecular:685 Sequence: N-Elaidoyl-KFK Purity: ≧95% Grade: cosmetic Source: synthetic Stability: stable Appearance: white powder MSDS and COA: available for your reference Delivery: promptly from stock 2.Usage: prevent age-associated dermal alterations防止年龄相关的皮肤改变 3. , Description：N-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF- beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK- mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of PMA-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations.

INCI Name:Tripeptide-1 Reference: Aldenine, Liporeductyl, Kollaren,Hilurlip, Prezatide, Liver cell growth factor Cas No: 72957-37-0 EINECS number: 277-125-4 Formula: C14H24N6O4 Molecular:340.5 Sequence: GHK Purity: >95% Grade: cosmetic Source: synthetic Odor: no Stability: stable Formulation: available for your reference Delivery: promptly from stock Capacity: 5kg per month Recommended use level: 1 - 10%. Appearance: white powder 2.Functions: Tripeptide-1 Increases skin firmness, Improves tissue renewal & healing 3.Introduction：Tripeptide-1 possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (GHK-Cu). This growth-modulating plasma tripeptide, when added at nanomolar concentrations to a wide group of cultured systems, produces a disparate set of responses ranging from the stimulation of growth and differentiation to outright toxicity. It may function by facilitating copper uptake into cells. GHK-Cu accelerates wound healing.

INCI Name:  palmitoyl lysyl-aminovaleroyl-lysine Reference: Anew Ultimate Age Repair Night Cream Formula: C33H65N5O5 Molecular: 611.90 Purity: >95% Odor: no Grade: cosmetic Source: synthetic Stability: stable Appearance: white powder Formulation: available for your reference Delivery: promptly from stock Recommended use level:  2.Functions: Palmitoyl Lysyl Aminovaleroyl Lysine in an amount effective to increase fibronectin levels in skin cells

Basic Fibroblast Growth Factor (bFGF) is a member of the FGF family of mitogenic peptides which is comprised of at least 23 proteins. FGF signaling factors play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. It was originally named bFGF based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Synonyms: FGF-2, Fibroblast Growth Factor basic (FGFb) Grade: cosmetic Source: Escherichia coli Purity: >95% by SDS-PAGE and HPLC analyses. Physical Appearance: White lyophilized powder. Endotoxin: < 1EU/ug of growth factor as determined by LAL method. AA Sequence MTMITNSSSV PGDPLESMAA GSITTLPALP EDGGSGAFPP GHFKDPKRLY CKNGGFFLRI HPDGRVDGVR EKSDPHIKLQ LQAEERGVVS IKGVCANRYL AMKEDGRLLA SKCVTDECFF FERLESNNYN TYRSRKYSSW YVALKRTGQY KLGPKTGPGQ KAILFLPMSA KS Molecular Weight: Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 172 amino acids Biological Activity: Fully biologically active. The ED50 is < 1.0ng/ml, corresponding to a specific activity of 1.0×106 Units/mg, as determined by the proliferation of BALB/c 3T3 cells. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, containing 4% mannitol. Reconstitution: Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Storage: Store at -20oC after receiving. Upon reconstitution, store at 2-8oC for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. Usage: This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.

Keratinocyte Growth Factor-2 (KGF-2) was originally identified from rat embryos by homology-based polymerase chain reaction. Human and mouse KGF-2 were subsequently cloned. The human KGF-2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF-2 shares approximately 92% and 95% amino acid sequence identity with mouse and rat KGF-2, respectively. Among the FGF family members, KGF-2 is most closely related to FGF-7. KGF-2 transcripts has been shown to be most abundant in the embryo and adult lungs. Recombinant KGF-2 preparations have been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. Based on its in vitro biological activities and in vivo expression pattern, KGF-2 has been proposed to play unique roles in the brain, in lung development, wound healing and limb bud formation.

Name: EGF,Recombinant human epidermal growth factor (rhEGF) CAS No.: 62253-63-8 Grade: cosmetic INCI Name: Human Oligopeptide-1 Source: E. coli Endotoxin level: less than 0.1 ng per μg (1EU/ug). 2.Introduction: EGF secreted by each of us, when we were in child times the secretion is the highest, and then it decreased with age increases. Particularly, After 22 years of age, reduced secretion was more pronounced. When we use cosmetics containing EGF, absorbed through the skin, added EGF of our skin exogenously, so that it can make our skin to restore the young state. We use E.coli by genetic engineering expressed, produced high purity EGF by biological fermentation. It was named Recombinant human epidermal growth factor (rhEGF). rhEGF have same structure with Human epidermal growth factor (EGF), it is a 6.2kDa protein.EGF stimulates the proliferation and differentiation of epithelial cells from skin, the cornea, lung and tracheal tissue and the gastrointestinal tract. EGF also promotes the proliferation of fibroblasts and embryonic cells. Thus, EGF plays an important role in wound healing and organogenesis. EGF is a highly efficient cell division factor with many other biological effects, which mainly includes: 1. stimulating the growth and proliferation of skin, cornea and tracheal epithelium tissue in vivo. 2. Accelerating the healing process of epidermis damage on skin, cornea, etc. 3. Repressing the gastric acid excretion. 4. Accelerating the proliferation of epithelial cells in human and animals. 5. Facilitating the biosynthesis of protein, RNA, DNA as well as metabolic activity in epidermal cells. 3.Usage First of all, put the EGF dissolved in distilled water. Wait the temperature of cosmetic cream decreased to below 40 degrees Celsius, then put the dissolved solution into the cream, stir the cream to full blending them.

INCI Name: Palmitoyl Dipeptide-5 Diaminohydroxybutyrate Cas No: 794590-34-4 Formula: C35H63F6N5O9 Molecular:811.89 Sequence: Palm-Lys-Val-Dab Purity: >95% Source: synthetic Odor: no Solubility: soluble in water Preparation: warm (for maximum 2 hours at 80°C) or cold Additive: 100 PPM MSDS and COA : available for your reference Capacity: 1kg per month Appearance: white powder 2.Functions: 1.Improves skin tonicity, firmness, and suppleness after only two months 2.Improves nutrient exchange, reduces signs of premature skin ageing and damage 3.Smoother skin and reduced appearance of wrinkles 4.Rejuvenated, more compact skin 3.Application: 1.Anti-wrinkle and anti-ageing products 2.Skin restructuring and smoothing products 3.Skin nourishing and skin repair treatments

Minimum Order: 1 bags

INCI Name: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine Reference: SYN-Tacks Cas No: 883558-32-5 Formula: C39H70F6N6O11 Molecular: 913 Sequence: Palm-Lys-Val-Dab-Thr Purity: >95% Solubility: soluble in water Grade: cosmetic Odor: no Source: synthetic Preparation: warm (for maximum 2 hours at 80°C) or cold MSDS and COA : available for your reference Capacity: 1kg per month Appearance: white powder 2.Functions: 1. SYN-Tacks Improves skin tonicity, firmness, and suppleness after only two months 2. SYN-Tacks Improves nutrient exchange, reduces signs of premature skin ageing and damage 3. SYN-Tacks Smoother skin and reduced appearance of wrinkles 4. SYN-Tacks Rejuvenated, more compact skin 3.Application: 1.Anti-wrinkle and anti-ageing products 2.Skin restructuring and smoothing products 3.Skin nourishing and skin repair treatments

Minimum Order: 1 bags

INCI Name: Dipeptide-4 Reference: Quintescine Cas No: 24587-41-5 Formula: C20H21N3O3S Molecular: 351 Purity: >95% Formulation: available for your reference MSDS and COA: available for your reference Source: synthetic Grade: cosmetic Delivery: promptly from stock Capacity: 1kg per month Appearance: white powder 2.Functions： 1. Dipeptide-4 Helps preserve the skin from oxidative stresses 2. Dipeptide-4 Helps improve the natural defense mechanisms against oxidative stresses (SOD and catalase) 3. Dipeptide-4 Helps protect against glycation damage 3.Description: Dipeptide-4 is a glutathione-biomimetic antioxidant peptide designed to help preserve against glycation damage. It helps protect skin from environmental stresses and prevents loss of skin resiliency. Recommended use level: 0.25 to 2.5 percent

Minimum Order: 1 bags

INCI Name: Acetyl dipeptide-3 aminohexanoate Reference: Bodyfensine Formula: 270 Molecular: C11H20N5O3 Source: synthetic Grade: cosmetic Purity: >95% Additive: 2-5% COA and MSDS: available for your reference Capacity: 500g per month Appearance: white powder 2.Usage：Human β-defensin-2 and -3 mimetics that reinforce skin’s natural immunity and lower risk of possible infections from external agents 3.Description: Acetyl dipeptide-3 aminohexanoate is a new tripeptide discovery that reinforces the skin’s natural defense mechanism, promoting optimal skin fitness, especially in acne--prone skin. Bodyfensine Reinforces the skin’s innate immunity, stimulating the first line of defense between the skin and the environment. Lowers the risk of possible infections by external agents in acne-prone skin.

Minimum Order: 1 bags

Vinblastine sulfate is an antineoplastic drug CAS:143-67-9 Product name Vinblastine Sulfate Cas No. 143-67-9 Molecular Formula C46H60N4O13S Appearance White fine powder Vinblastine Sulfate Is an Antineoplastic Drug CAS: 143-67-9 Vinblastine Sulfate Is an Antineoplastic Drug CAS: 143-67-9 Vinblastine Sulfate Is an Antineoplastic Drug CAS: 143-67-9 Vinblastine Sulfate Is an Antineoplastic Drug CAS: 143-67-9 Vinblastine sulfate is a national basic drug, mainly used for the treatment of Hodgkin's disease and malignant lymphoma. It can also be used for the treatment of choriocarcinoma and breast cancer. It can also be used for bronchial lung cancer, soft tissue sarcoma, testicular tumor, ovarian cancer, Digestive tract cancer, vicious cycle melanoma and neuroblastoma are one of the most widely used natural plant anticancer drugs in the world. hot product:77591-33-4,520-36-5,121062-08-6,506-32-1,5 , 7773-65-6,144-55-8,501- 36-0,70288-86-7,9004-61 , -9,57-83-0,83701-22-8,1190307-88-0,1379686-30-2,52 , -61- 9,131707-23-8,182410-00-0,38340-91-5,331-3 , 9-5,157115-85-0,17465-86-0,35-128446- 5,54965-2 , 1-8, 147403-03-0,55-13422-4,35-132112-7,56-2252403-6

Minimum Order: 86

Gs-441524 is phosphorylated into nucleoside monophosphate (NMP) by cytokinase in cells, and then transformed into an active triphosphate metabolite (NTP structural analogue). In viral RNA synthesis, the active NTP analogues compete with the naturalnucleosides (ATP, TTP, CTP, GTP) to participate in RNA transcription. When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.

Minimum Order: 185

Product Name Antiparasitic Drugs Ivermectin Powder CAS: 70288-86-7 Appearance White Powder Assay 99%min Ivermectin Test HPLC CAS 70288-86-7 MF C95H146O28 Storage Temperature Cool Dry Place Antiparasitic Drugs Ivermectin Powder CAS: 70288-86-7 Ivermectin is a new semi-synthetic antibiotic insecticide, acaricide and nematocide, which belongs to insect nerve agent and biological permeable agent. The mechanism of action is to interfere with the neurophysiological activities of pests, stimulate the release of γ-aminobutyric acid, acting on the nerve and muscle joints, increase the release of chloride ions, inhibit the information transmission of nerve joints, resulting in paralysis of pests and harmful mites and poisoning death. Its product is colorless or light brown yellow liquid. Ivermectin is a new type of broad-spectrum, high efficiency and low toxicity antibiotic against parasites, especially nematodes and arthropods. But not for tapeworms, flukes and protozoa. Large ring lactone class parasite drug resistance to nematodes and the function of flooding killed by arthropods, is to increase the insect body inhibitory neurotransmitter gamma aminobutyric acid (GABA) release, and open the glutamic acid control Cl ion channels, strengthen the nerve membrane permeability of Cl, thereby blocking nerve signal transmission, nerve palsy, eventually lose muscle contraction ability, This causes the worm to die. Applications: 1.Ivermectin, an antibiotic drug, has antifungal activity against nematodes, insects and mites. The injection tablets made of Ivermectin are mainly used for the treatment of gastrointestinal nematodes in domestic animals, such as cattle fly maggots, skin fly maggots, sheep nose fly maggots and pig sheep scabies. In addition, Ivermectin can also be used for the treatment of parasitic nematodes in domestic animals (such as roundworm lungworm, etc.). It can also be made into agricultural insecticide and acaricide, which is used to kill the mites widely parasitic on plants, such as Diamond-moth, cabbage, leaf beetle, woodlice, nematode and so on 2.It is effective in the treatment and control of onchocerciasis, and its adverse reaction is lower than that of ethy'lamine 3.Antiparasitic drugs, antiparasitic activity against nematode, hookworm, roundworm, worm and mites

Minimum Order: 1 bags

Anticoagulant drugs Heparin Sodium CAS: 9041-08-1 with antiplatelet drugs Prodcut name Heparin sodium MOQ 100g CAS No. 9041-08-1 Appearance crystall , ine powder Molecular Formula (C12H16NS2Na3)20 Assay 99 , % Application Pharma grade or research purpose Packing As per your request Storage Preserve in tight, light-resistant containers in a cool place Remarks NA Custom synthesis Available Supply Ability 500kg/month Heparin Sodium Prevents Blood Embolism CAS: 9041-08-1 Anticoagulant Drugs Heparin Sodium Prevents Blood Embolism CAS: 9041-08-1 Anticoagulant Drugs Heparin Sodium Prevents Blood Embolism CAS: 9041-08-1 Anticoagulant Drugs Heparin sodium may be used in the treatment of acute thromboembolic disease, disseminated intravascular coagulation (DIC). In recent years, heparin has been found to clear blood fat. Heparin sodium has low toxicity and the tendency to spontaneous bleeding is the main risk of heparin overdose. Oral ineffective, must be administered by injection. Intramuscular injection or subcutaneous injection is more irritating, occasionally allergic reaction, exceeding the amount may even cause cardiac arrest; Heparin Sodium (Heparin Sodium) is Heparin Sodium sulfate glycosaminoglycan anticoagulants.In recent years, studies have shown that heparin and fall hematic fat action. Heparin sodium is an anticoagulant and sticky polysaccharide substance. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. In human body, it is secreted by mast cells and naturally exists in blood. Heparin sodium can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and fight against the formed thrombin, prevent the transformation of prothrombin into thrombin and the effect of antithrombin. Heparin sodium can delay or prevent blood clotting in vivo and in vitro. The mechanism of its action is very complex, and it affects many links in the process of coagulation. Its role is: (1) inhibit the formation and function of thromboplastin, so as to prevent prothrombin into thrombin; (2) It can inhibit thrombin and other clotting factors in high concentration fashion, and prevent fibrinogen from becoming fibrin; (3) can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is related to the negatively charged sulfate in its molecules, and the positively charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect. Because heparin can activate and release lipoprotein esterase in the body, hydrolyze the triglyceride and low-density lipoprotein of chylomicron, it also has the effect of lowering blood lipid. Functions and Applications: 1.The treatment of various diseases concurrent disseminated intravascular coagulation early. 2.Prevention of arterial and venous thrombosis and pulmonary embolism. 3.Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina (to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of early reinfarction and infarct extension, reduce mortality). 4.The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants. 5.thrombolytic therapy as maintenance therapy. 6.used for the prevention of blood coagulation and blood bank transfusion of blood and other body save anticoagulants.

Minimum Order: 1 bags