Safe Shipping Sarms SR9011 powder for bodybuilding cycle for sale CAS:13796

Product Name: SR9011
CAS No.: 1379686-30-2
Molecular formular: C20H24ClN3O4S
Molecular Weight: 437.94
Appearance: White powder
Purity: 99.% min
Package: 10g/bag or as customers'request.
Test Method: HPLC

Benefit：SR9011 suppressed the expression of BMAL1 messenger RNA in HepG2
cells in a REV-ERB-a/b-dependent manner. Moreover, SR9011 inhibited the
activity of the SCNclock, with reversible inhibition of circadian
oscillations.
The C-terminal of sr9011 family proteins lacks a ligand binding domain, but
the expression of Rev Erb protein can be inhibited by recruiting nuclear
receptor inhibitors and histone deacetylase 3. Histone deacetylase 3 is a
rev Erb agonist and a small molecular chemical probe. Fon Taine et al. First
reported that sr9011 has a correlation with inflammation, sr9011 can inhibit
the expression of TR4, thus controlling the inflammatory signal. Foreign
scholars have found that in human macrophages, the increase of sr9011 mRNA
expression by pharmacological methods directly leads to the decrease of pro-
inflammatory factor IL-6 mRNA expression.
Sr9011 increased the expression of chimeric Gal4 DNA binding domain in
HEK293 cells in a dose-dependent manner to evaluate Rev Erb dependent
inhibitory activity (DBD) - Rev Erb ligand binding domain (LBD) α or β and
Gal4 responsive luciferase (Rev Erb α IC50 = 790 nm, Rev Erb β IC50 = 560
nm).


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Minimum Order: 10 grams