Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6

Product Name: GW0742
CAS:317318-84-6
FW:C21H17F4NO3S2
MW:471.4846
Appearance: White powder
Purity: 99.% min
Package: 10g/bag or as customers'request.
Test Method: HPLC

Benefit:The effects of a high-affinity PPAR-β/δ agonist, GW0742, in a
mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the
pleural cavity of mice elicited an acute inflammatory response characterized
by accumulation of fluid containing a large number of neutrophils
(polymorphonuclear leukocytes) in the pleural cavity, infiltration of
polymorphonuclear leukocytes in lung tissues and subsequent lipid
peroxidation, and increased production of nitrite/nitrate, TNF-α, and IL-
1β. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and
nitrotyrosine formation was determined by immunohistochemical analysis of
lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before
and 30 min after a challenge with CAR caused a reduction in all the
parameters of inflammation measured. Thus, based on these findings, we
propose that a PPAR-β/δ agonist such as GW0742 may be useful in the
treatment of various inflammatory diseases.

Application:GW0742 is a potent and selective agonist for PPARδ, a member of
the PPAR subfamily of the nuclear receptor superfamily of transcription
factors. It has been shown to reduce atherosclerosis in LDLR-/- mice, to
exert protective actions in an autoimmune model of demyelinating disease,
and to induce differentiation and inhibit proliferation in keratinocytes.

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Minimum Order: 10 grams

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