Repaglinide Tablets

Repaglinide tablets are non-sulfonylurea insulin secretion agents and are used
to treat patients with type 2 diabetes. Repaglinide tablets were listed in
China in 2000, and it is a Class B drug in the National Medical Insurance List.
Repaglinide tablets have been listed as a drug for diabetic patients with renal
insufficiency by many guidelines at home and abroad.

Product name: Repaglinide Tablets

Characteristic: White or off-white tablet

Specification: repaglinide 0.5 tablet×30 tablets, repaglinide 0.5mg×60
tablets.

Indications：

It is used for type 2 diabetes (non-insulin-dependent) patients whose
hyperglycemia cannot be effectively controlled by diet control, weight loss and
exercise. When metformin alone cannot effectively control hyperglycemia,
Repaglinide tablets can be combined with metformin. Treatment should start from
the adjuvant treatment of diet control and exercise to reduce blood sugar
during meals.

Specifications of Repaglinide Tablets: 0.5mg

Usage and Dosage，Adverse reactions，Contraindications，Precautions：
,
Please refer to the package insert.

Medicine Interactions:

Some drugs are known to affect glucose metabolism. Therefore, doctors should
consider possible drug interactions.

In vitro studies have shown that the metabolism of Repaglinide is affected by
CYP2C8 and CYP3A4. Repaglinide was found to be a substrate for active liver
uptake (organic anion transporter OATP1B1).

Data from clinical studies carried out in healthy volunteers show that CYP2C8
is the main enzyme in the metabolism of Repaglinide, while CYP3A4 has limited
effects. But if the effect of CYP2C8 is inhibited, the effect of CYP3A4 will be
relatively enhanced. Therefore, the metabolism and clearance of Repaglinide may
be changed due to the inhibition or induction of cytochrome P450. Therefore,
extreme caution should be exercised when using CYP2C8 and CYP3A4 inhibitors
simultaneously with Repaglinide. Drugs that inhibit OATP1B1 (such as
cyclosporine) may increase the plasma concentration of Repaglinide. ( For more
details, please refer to the package insert.)

Storage: Similar to the storage of glimepiride tablets, tab repaglinide should
also be shaded, sealed, kept in a dry place.

Packaging:

Aluminum plastic packaging, 15 pills/plate , 2 plates/box; 15 pills/plate, 4
plates/box, 15 pills/plate, 6 plates/box

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Minimum Order: 20 bags

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