Nooglutyl CAS No.:112193-35-8 99.0% purity min. Promoting intelligence

Product name:Nooglutyl
Other name :Nooglutil;
N-[(5-Hydroxy-3-pyridinyl)carbonyl] , -L-glutamicacid;N-[(5-Hydroxypyridin-3-
yl)carb , onyl]-L-glutamicacid;
ONK-10;
L-GlutaMicacid , ,N-[(5-hydroxy-3-pyridinyl)carbonyl]-;
N-(5-hyd , roxynicotinoyl)-L-glutamicacid
CAS No. 112193-35-8
Molecular formula:C11H12N2O6
Molecular weight:268.22
Purity:99.0%
Appearance :White or almost white powder
Application:Dietary Supplement Raw Material
3.Product introduction
Nooglutyl is a nootropic agent being studied at the Research Institute of
Pharmacology, Russian Academy of Medical Sciences as a potential treatment for
amnesia.
In animal models, it has a variety of central nervous system effects.
Experiments on rats demonstrate that nooglutyl exhibits pronounced vestibular-
protective properties and by its antimotion activity does not rank below classic
vestibular protectors, such as scopolamine and diprazine. Electrophysiological
experiments on cats show that nooglutyl alters spontaneous activity in 80% of
cortical neurons (somatosensory zone I and area 5 of the parietal association
cortex) and considerably weakens effects caused by motion sickness: activation of
single unit activity of somatosensory zone I and inhibition of neuron responses to
somatic stimulation. This property of the preparation is believed to form the basis
of its antimotion effect.
4.Features
(1) High purity: Nooglutyl preparation can obtain high-purity products through
natural extraction and fine manufacturing process. High purity means better
bioavailability and fewer adverse reactions.
(2) Safety: Nooglutyl is a natural product that has been proven to be safe to
humans. Within the dosage range, it has no toxicity or side effects.
(3) Stability: Nooglutyl preparation has good stability and can maintain its
activity and effect under different environmental and storage conditions.
(4) Easy to absorb: Nooglutyl preparation can be quickly absorbed by the human
body, enter the blood circulation through the intestinal tract, and distribute to
different tissues and organs.
5.Applications
The neuroprotective properties of the positive modulator of AMPA subtype of
glutamatergic receptors Nooglutyl （N－（5－oxynicotinoyl）L－glutamic acid）－the
agent with nootropic and anti-hypoxic activities, were studied in the models of
intracerebral post－ traumatic hematoma（hemorrhagic stroke，HS）and occlusion of
the middle cerebral artery （ischemic stroke）in rats. Nooglutyl at a dose of 10 mg
／kg diminished HS-induced neurological deficit，movement coordination disturbances
improved the memory in conditioned passive avoidance task and increased the
survival in HS model. The volume of ischemic damage caused by the occlusion of
distal fragments of the left middle cerebral artery （OMCA）was shown to be 22.51％
of ipsilateral hemisphere volume in the saline treated rats. Mexidol at adose of 50
mg/kg injected i.v. during OMCA diminished the volume of the damage up to 6.5％.
These findings suggest the neuroprotective profile of Nooglutyl action.

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