HPMC E6

Kima chemical®HPMC E6 Hydroxypropyl methylcellulose is a non-ionic cellulose
mixed ether made from cotton and wood through alkalization, propylene oxide and
methyl chloride etherification. It is odorless, tasteless, non-toxic, soluble
in cold water and gelled in hot water. Hydroxypropyl methylcellulose is a
cellulose mixed ether variety whose production, dosage and quality have been
rapidly increasing in China in the past 15 years. It is also one of the most
widely used pharmaceutical excipients at home and abroad.

Specification of HPMC E6
HPMC E6
Hydroxypropyl Methyl Cellulose (HPMC)
Physical Analysis
Appearance White to slightly off-white fibrous or granular powder.
Identification A to E Conform
Solution appearance Conform
Methoxy 28.0-30.0%
Hydroxypropoxy 7.0-12.0%
Loss on drying 5.0% Max
Residue on ignition 1.5% Max
pH 5.0-8.0
Apparent viscosity 4.8-7.2cps
Particle size Min. 98% pass through 100 mesh
Heavy Metals
Heavy Metal ≤10ppm
Arsenic ≤3ppm
Lead ≤3ppm
Mercury ≤1ppm
Cadmium ≤1ppm
Micro bacteria
Total plate count ≤1000cfu/g
Yeast and Mould ≤100cfu/g
Coli form Absent/g
Salmonella Absent/g

Application of HPMC E6

KimaCell® HPMC E6 is widely used in pharmaceutical excipients. The application
of HPMC is mainly reflected in the following five aspects:

As a suspending agent.

Suspension-type liquid preparation is a commonly used clinical dosage form,
which is a heterogeneous dispersion system in which insoluble solid drugs are
dispersed in a liquid dispersion medium. The stability of the system determines
the quality of the suspension liquid preparation. HPMC colloidal solution can
reduce the solid-liquid interfacial tension, reduce the surface free energy of
solid particles, and stabilize the heterogeneous dispersion system. It is an
excellent suspending agent. HPMC is used as a thickener for eye drops, with a
content of 0.45% to 1.0%.

As a binder and disintegrant.

As a binder, HPMC can make the drug easy to wet, and it can expand hundreds of
times after absorbing water, so it can significantly improve the dissolution
rate or release rate of the tablet. HPMC has strong viscosity, which can
enhance the particle viscosity and improve the compressibility of raw materials
with crisp or brittle texture. HPMC with low viscosity can be used as binder
and disintegrant, and those with high viscosity can only be used as binder.

As a sustained and controlled release material for oral preparations.

HPMC is a commonly used hydrogel matrix material in sustained-release
preparations. Low viscosity grade (5-50mPa·s) HPMC can be used as binder,
viscosifier and suspending agent, and high-viscosity grade (4000-100000mPa·s)
HPMC can be used to prepare mixed material matrix sustained-release tablets,
Blocking agent for capsules, hydrogel matrix extended-release tablets. HPMC is
soluble in gastrointestinal fluid, has the advantages of good compressibility,
good fluidity, strong drug loading capacity, and drug release characteristics
not affected by pH. It is an extremely important hydrophilic carrier material
in sustained-release preparation systems and is often used as Hydrophilic gel
matrix and coating materials for sustained-release preparations, as well as
auxiliary materials for gastric floating preparations and sustained-release
drug film preparations.

As a coating film-forming agent.

HPMC has good film-forming properties. The film formed by it is uniform,
transparent and tough, and it is not easy to stick during production.
Especially for drugs that are easy to absorb moisture and are unstable, using
it as an isolation layer can greatly improve the stability of the drug and
prevent The film changes color. HPMC has a variety of viscosity specifications.
If selected properly, the quality and appearance of coated tablets are superior
to other materials. The commonly used concentration is 2% to 10%.

As capsule material.

In recent years, with the frequent outbreaks of global animal epidemics,
compared with gelatin capsules, vegetable capsules have become the new darling
of the pharmaceutical and food industries. Pfizer of the United States has
successfully extracted HPMC from natural plants and prepared VcapTM vegetable
capsules. Compared with traditional gelatin hollow capsules, vegetable capsules
have the advantages of wide adaptability, no risk of cross-linking reactions
and high stability. The drug release rate is relatively stable, and individual
differences are small. After disintegration in the human body, it is not
absorbed and can be excreted The substance is excreted from the body. In terms
of storage conditions, after a large number of tests, it is almost not brittle
under low humidity conditions, and the properties of the capsule shell are
still stable under high humidity conditions, and the indicators of plant
capsules are not affected under extreme storage conditions. With people's
understanding of plant capsules and the transformation of public medicine
concepts at home and abroad, the market demand for plant capsules will grow
rapidly.

Minimum Order: 1 tons

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