HPMC E15

KimaCell®HPMC E15 Hydroxypropylmethylcellulose is a water-soluble cellulose
polymer that helps optimize the solubility enhancement of poorly soluble drugs
by maintaining a stable solid dispersion and inhibiting API crystallization.

More sophisticated drug discovery techniques have resulted in pipeline
compounds requiring enhanced solubility to achieve therapeutic efficacy. Solid
dispersion is one of the key technologies for formulating oral solid dosage
forms containing APIs with bioavailability challenges. HPMC E15 is
specifically designed for the production of solid dispersions in the
pharmaceutical industry by spray drying or hot melt extrusion.

HPMC E15 Properties
HPMC E15
Hydroxypropyl Methyl Cellulose (HPMC)
Physical Analysis
Appearance White to slightly off-white fibrous or granular powder.
Identification A to E Conform
Solution appearance Conform
Methoxy 28.0-30.0%
Hydroxypropoxy 7.0-12.0%
Loss on drying 5.0% Max
Residue on ignition 1.5% Max
pH 5.0-8.0
Apparent viscosity 12-18cps
Particle size Min. 98% pass through 100 mesh
Heavy Metals
Heavy Metal ≤10ppm
Arsenic ≤3ppm
Lead ≤3ppm
Mercury ≤1ppm
Cadmium ≤1ppm
Micro bacteria
Total plate count ≤1000cfu/g
Yeast and Mould ≤100cfu/g
Coli form Absent/g
Salmonella Absent/g

HPMC E15 Viscosity
HPMC E15 refers to Hydroxypropyl Methyl Cellulose with a nominal viscosity of
12.0-18.0 centipoises (cPs). The viscosity of HPMC E15 can vary slightly
depending on the concentration and temperature of the solution it is dissolved
in. However, the nominal viscosity value of 12-18 mPa.s provides a general
indication of its viscosity range.

Viscosity is a measure of a fluid's resistance to flow. In the case of HPMC
E15, the higher viscosity indicates that it forms a more viscous solution
compared to lower viscosity grades of HPMC. This property makes it suitable for
applications that require thicker and more stable formulations.

It's important to note that the viscosity of HPMC E15 can be further adjusted
by varying the concentration of the HPMC powder in the solution. Higher
concentrations of HPMC will generally result in higher viscosity solutions.

When using HPMC E15 in formulations, it is advisable to consult the
manufacturer's technical data sheet or product specifications for precise
information on viscosity and recommended usage levels. The technical data
provided by the manufacturer will offer detailed information on the viscosity
range, methods of measurement, and guidelines for formulating with HPMC E15.

HPMC E15 Uses

KimaCell® HPMC E15 is widely used in pharmaceutical excipients.

Tablet adhesive

HPMC E15 can be used as a binder for wet granulation of tablets at 3-5% of the
finished tablet weight. HPMC E15 produces stronger granules compared to
granules made with HPMC E15, which means that disintegration and dissolution
times may be affected as harder tablets are produced.

Thickener and suspending agent

HPMC E15 can be used as a viscosity modifier in many cream, ointment,
suspension formulations, including ophthalmic formulations.

KimaCell E15 grade is used in systems where high transparency is required and
ease of filtration is an important parameter.

As one of cellulose ether suppliers, we will do our best to meet all the needs
of customers.

Minimum Order: 1 tons

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