Hesperetin

Hesperetin CAS No.520-33-2
Product name Hesperetin
Herbal Source Citrus Aurantium L.
CAS NO 520 33 2
Hesperetin Chemical Formula C16H14O6
Hesperetin Molecular Weight 302.27
Specifications 90.0%, 95.0%, 98.0%
Test Method HPLC
Appearance Light yellow to off-white powder

Hesperetin Solubility Easily soluble in ethanol, soluble in diluted alkali
solution, partly soluble in diethyl ether, slightly soluble in water,
chloroform and benzene.
Hesperetin Food Sources Citrus Fruits and Juices.


Hesperetin is a kind of natural flavonoid compound, widely existing in the
fruits of rutaceous plants. Hesperidin and hesperetin have a close relationship
with each other. Hesperetin mainly comes from decomposed enzymatically
hesperidin with the appearance of light yellow or off-white powder. Hesperetin
structure is very complex with the three hydroxy groups located at the 3'-, 5-
and 7-positions and an additional methoxy substituent at the 4'-position.
Hesperetin is widely used in the food, nutraceutical and cosmetics industries.

Hesperetin was listed in FEMA as the raw material of flavours and fragrances in
2007 with FEMA No. 4313 and also listed in SFDA GB2760 in 2017 with No.N375.

As one of the professional natural extracts manufacturers, Chengdu Kindarco
Biotech provides various kinds of hesperetin products with high quality. If you
want to buy hesperetin products, please contact us!
Hesperetin benefits for health
Hesperetin has a wide range of pharmacological effects. Hesperetin will not
accumulate in any organs, it is safe to use and has no obvious side effects.
Early research on the pharmacological effects of hesperetin mainly focused on
anti-bacterial, anti-inflammatory, anti-oxidant, anti-viral, anti-allergic,
regulation of blood lipids, enhancement of immunity and anti-cancer.

Benefits of Hesperetin for Food and Flavors
1. Hesperetin can enhance the sweet taste of sweet-tasting substances, and
reduce the amount of sucrose used.

2. Hesperetin can improve the unpleasant taste of food, and increase the degree
of deliciousness.

3. Hesperetin can enhance the sweet olfactory impression of sweeteners.

Benefits of Hesperetin Supplement as Nutraceuticals
1. Hesperetin is a kind of antioxidant plant extract. And hesperetin supplement
has the remarkable function of anti-inflammation and antioxidant.

2. Hesperetin supplement has significant regulation and inhibition function of
cardiovascular protection and reducing blood lipid.

3. Hesperetin can reduce toxicity damage of nervous excitability and play a
role in protecting the nervous system.

Benefits of Hesperetin Used in Cosmetics
1. Protect skin from environmental damages and prevent tanning and sunburn.

2. Improve microcirculation, and eliminate the related symptoms of
microcirculation (such as dark circles).

3. Prevent skin ageing symptoms, improve skin dullness, and make the skin
become smooth and flexible.

4. Control the formation of sebum, and prevent skin acne;

5. Hesperetin can be esterified with lauric acid to obtain hesperetin laurate,
which is widely used in cosmetics.

What is Hesperetin Used For?
Hesperetin is one type of citrus fruit extracts and often used in food,
medicine, health-care products and cosmetics. Hesperetin and its derivatives
can be used in the treatment of Alzheimer's disease, Parkinson's disease,
hyperglycemia, venom hemagglutinin, anti-lung, kidney, and liver fibrosis, and
inhibit some new tumors. For example, Parkinson’s disease (PD) is a
neurodegenerative disease caused by the loss of dopaminergic nerve cells in the
brain. Hesperetin has a positive effect on cell apoptosis, inflammation and
oxidative stress. In addition, hesperetin has an anti-snake venom hemagglutinin
effect, is a non-competitive SVSP1 and SVSP2 inhibitor, and can be used as a
low-cost inhibitor for the study of snake venom protease. If you want to know
more, please contact us.

Hesperidin and Hesperetin: What's the Difference?
Hesperetin and Hesperidin are different substances. Hesperetin is a chemical
substance with a molecular formula of C16H14O6. It is mainly derived from young
fruits of the citrus genus of the Rutaceae family, which belongs to one of the
dihydroflavonoids. It is light yellow needle-like crystal or powder. Hesperidin
is also known as Chuanpisu; Dihydroflavonoid glycosides, molecular formula
C28H34O15, are white or light yellow crystalline powder; odorless and
tasteless. It is easily soluble in pyridine or dimethylformamide, but insoluble
in ethanol or water. But the functions of the two are similar. Both have the
functions of anti-oxidation and elimination of free radicals, regulating the
cardiovascular system, and can protect the nervous system, anti-allergic and
dermatitis, anti-bacteria and microorganisms, anti-cancer and genotoxicity.

Technical Data Sheet (TDS) of Hesperetin Powder


If you want to know more details of hesperetin uses, please contact us.

We have different types of plant extracts for sale, if you have needs, please
visit our website.

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