Hanhong Benzocaine 99% purity CAS 94-09-7 powder

Hanhong Benzocaine 99% purity CAS 94-09-7 powder

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Prod , uct Name: Benzocaine
CAS: 94-09-7
MF: C9H11NO2
MW: 165.19
EINECS: 202-303-5
Mol File: 94-09-7.mol

Benzocaine is a local anaesthetic of the ester type with a poor solubility in
water. The drug benzocaine is normally used as a topical pain reliever or as a
common ingredient in cough drops. Benzocaine is used in multiple forms
including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied
in any form it temporarily numbs or blocks the nerve endings, which leads to a
decreases in the amount of pain. It is used in cattle, sheep, swine and horses
for local and prolonged low epidural anaesthesia. Standard therapeutic doses of
benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently
used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and
ulcerated surfaces in horses, cattle and sheep applied twice a day until
healing.
A commonly used topical pain reliever. Main active ingredient in anesthetic
ointments.
Anesthetic;Na+ channel blocker
Benzocaine acts on the central nervous system, cardiovascular system,
neuromuscular junctions and ganglion synapse. Its mechanism of action is to
prevent the generation and conduction of the nerve impulse. Local anaesthetics
block conduction by decreasing or preventing the large transient increase in
the permeability of excitable membranes to Na+ that is produced by a slight
depolarisation. This action of local anaesthetics is due to their direct
interaction with voltage-sensitive Na+ channels. Benzocaine is mainly
hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the
action of sulphonamides.
Benzocaine is distributed in the body, crosses the placenta and is metabolised
in the liver and in the plasma by non-specific cholinesterases. Benzocaine and
its main metabolite (para-aminobenzoic acid) are excreted into urine.
Benzocaine appears as a moderately toxic compound after single administration.
The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may
induce methemoglobinemia in several species such as sheep, cats and dogs.

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