Glycosylation Peptides

A covalent alteration known as peptide glycosylation may enhance the
physicochemical characteristics of peptides. Increased bioavailability,
increased metabolic stability, targeting particular tissues and organs,
decreased clearance rates, improved receptor binding, facilitated active
transport across cell membranes (glucose transporters), and preservation of the
overall physical properties of peptides (precipitation, aggregation, thermal,
and kinetic denaturation) are some benefits of glycosylated peptides.

Glycan Polysaccharides
Many peptides can benefit from simple glycans, which are composed of just one
sugar molecule (such as D-galactose, D-glucose, or D-mannose), but in rare
circumstances, more complex glycans may be necessary. Site-specific
glycosylations of a variety of linear or branched glycan polysaccharides are
available from our technical team.

Common Glycosylated Amino Acids
Sugar Amino Acid Glycated Amino Acid Linkage
α-D-Galactose Serine Ser(alpha-D-GalNAc)
Tn Antigen O-linked
α-D-Galactose Threonine Thr(alpha-D-GalNAc)
Tn Antigen O-linked
β-D-Galactose Serine Ser(beta-D-GalNAc) O-linked
β-D-Galactose Threonine Thr(beta-D-GalNAc) O-linked
β-D-Galactose Serine Ser(Gal-beta(1-3)GalNAc)
Tf Antigen O-linked
β-D-Galactose Threonine Thr (Gal-beta(1-3)GalNAc)
Tf Antigen O-linked
β-D-Glucose Serine Ser(beta-D-GlcNAc) O-linked
β-D-Glucose Threonine Thr(beta-D-GlcNAc) O-linked
β-D-Glucose Asparagine Asn(beta-D-GlcNAc) N-linked
β-D-Glucose Serine Ser(beta-D-Glc) O-linked
α-D-Mannose Serine Thr(alpha-D-Man) O-linked
α-D-Mannose Asparagine Asn(alpha-D-Man) N-linked
α-D-Mannose Serine Ser(alpha-D-Man) O-linked
α-D-Mannose Threonine Thr(alpha-D-Man) O-linked

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