CT/X-Ray Contrast Media

The main component of CT/X-ray Contrast Media is iodine. The Iodinated Contrast
Media is a colorless, transparent, slightly viscous liquid. At present, the CT
contrast agents can be mainly divided into ionic and non-ionic, according to
the osmotic pressure can be divided into hypertonic, isotonic and hypotonic.
Currently, non-ionic, isotonic or hypotonic Contrast Media are used clinically.
When the CT contrast medium is injected, 97% of the contrast media products can
be directly excreted from the kidneys within 1 day.

Types of Contrast Media

Iohexol Injection

Iohexol Injection is non-ionic contrast agent. Compared with traditional ionic
contrast agent, Iohexol Injection has the excellent molecular structure, it has
greatly improved safety, and significantl...

Iopamidol Injection
Iopamidol Injection is the second-generation non-ionic iodinated contrast media
launched in the global market. In 2015, Beilu firstly launched and listed this
product in the Chinese market. Product name: Iopam...

Iodixanol Injection
Iodixanol Injection is a Contrast Media that is isotonic with plasma. It has
excellent cardiac safety and renal safety, which is most comfortable to use,
especially suitable for high risk patients.

Reasonable Use of Iodinated Contrast Agents

Evaluate patient benefits/risks before use

History of allergies: Patients who have previously experienced moderate to
severe anaphylactoid reactions to iodinated contrast agents or patients with a
history of allergies requiring treatment are at an increased risk of having an
allergic reaction to CT scan contrast dye.

Kidney function: iodinated contrast agents can cause acute kidney injury, and
patients should be evaluated for related risks before the surgery.

Combination medication: drugs that may increase the risk of adverse reactions
to iodinated contrast agents: neuroleptics and antidepressants, interleukin-2,
beta-blockers, metformin.

Situations where iodinated contrast agents should be used with caution: lung
and heart diseases, catecholamine secreting tumours, pregnant and lactating
women, myeloma and macroglobulinemia, myasthenia gravis, homocystinuria.

Contraindication: uncured patients with hyperthyroidism.

Dose limit for iodinated contrast agents

On the premise of satisfying imaging/diagnosis, the minimum dose of iodinated
contrast agents should be used.

For low-risk patients, the total dose of types of contrast agents had better be
controlled within 300 ~ 400 ml.

Maximum dose of iodinated radiocontrast dye

Method I *: 5 ml × body weight (kg)/serum creatinine (mg/dl) (not more than
300 ml) [refer to Cigarroa calculation formula]

Method II: 3.7 times creatinine clearance [according to 2011 ACCF/AHAUA/NSTEMI
Treatment Guidelines]

For those with severe renal insufficiency, try to choose an imaging method that
does not require iodine-based contrast agents or a non-imaging method that can
provide sufficient diagnostic information.

Avoid repeated use of the diagnostic dose of an iodinated contrast medium in a
short period of time. If repeated use is indeed necessary, it is recommended
that the interval between two MRI contrast agent applications be ≥14 days.

Other precautions for the use of iodinated contrast agents

Preheating: Before using an iodinated contrast agent, it is recommended to heat
the contrast agent to 37 °C and place it in a thermostat.

Hydration: It is recommended to hydrate patients within 6 to 12 hours before
using an iodinated contrast agent to within 24 hours after use. Hydration
method: Intra-arterial drug users are advised to receive intravenous
rehydration and oral rehydration concomitantly, and oral rehydration is
recommended for intravenous drug users.

Stay and observation: After the injection of the iodine-based contrast media,
the patient needs to stay and be observed for 30 minutes before leaving the
examination room.

Establish an emergency channel: Establish an emergency rapid support mechanism
for the rescue of adverse reactions caused by iodinated contrast agents with
the emergency room or other clinical related departments to ensure that after
an adverse reaction occurs, clinicians can promptly rush to the rescue scene
for rescue if necessary.

Prevention and Management of Vascular Extravasation of Iodinated Contrast
Agents

Prevention

Choose appropriate blood vessels for venipuncture and operate carefully; when
using a high-pressure syringe, choose a puncture needle and catheter that match
the injection flow rate; properly fix the puncture needle; communicate with the
patient and get cooperation.

Management

Mild extravasation: Most injuries are minor and need no treatment. However, the
patient should be instructed to keep observing. If the extravasation worsens,
the patient should seek medical attention in time. For individuals with
significant pain, common cold and hydropathic compresses can be given locally.

Moderate and severe extravasation: ① raise the affected limb to promote blood
return. ② Use 50% magnesium sulfate moisturizing cold compress in the
beginning, and after 24-hours change to magnesium sulfate moisturizing hot
compress, or use mucopolysaccharide ointment for topical application, or use
0.05% dexamethasone for local hydropathic compress. ③ Those with severe
contrast agent extravasation should be given oral dexamethasone 5 mg/time tid
for 3 consecutive days on the basis of topical drug use. ④ If necessary,
consult a clinician for medication.

Bei lu is a professional contrast media manufacturing companies, we provide ct
contrast agent, mri contrast medium, contrast media products and etc. Want to
know more? Please contact us.

Minimum Order: 20 bags

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