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Contact: beilupharma
Company: Beijing Beilu Pharmaceutical Co., Ltd
No.3 Shuiyuan West Road, Miyun District, Beijing,China
Beijing 101509
China
Phone: 15201108103
E-Mail: Send Inquiry Member for over 2 years
Date/Time:  1/11/22 5:57 GMT
 

Contrast Media Manufacturing Company

For the purpose of medical imaging, a certain substance is introduced into the
human body to change the image contrast of local tissues of the body. This
introduced substance is Contrast Media, also known as Contrast Agents. As the
first Contrast Media manufacturer in China, Beilu Pharma launched the domestic
MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the
foreign products monopoly and filled the domestic gap. As a well-known contrast
media manufacturing companies, we could provide a broad portfolio stems
Contrast Media across CT/X-ray and MRI modalities, and own the EU standard
manufacturing facilities.

Types of Contrast Media in Beilu Pharma

Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast
agent(GBCA). It is an intravenous injection, mainly used to enhance the image
quality of internal organs, blood vessels and tissues during MRI examinations.
GBCA contains gadolinium, which is connected to each other through carrier
molecules to form a chelating agent. According to the different chemical
structures, this contrast medium can be divided into two categories: linear and
macrocyclic. The linear structure of the imaging agents is easier to release
gadolinium ions, and the macrocyclic structure of the contrast material is more
stable and less likely to release gadolinium ions.

CT/X-RAY CONTRAST MEDIA

Iodine-containing Contrast Media is one of the common imaging contrast agents
used in radiology diagnosis and interventional therapy. It is also a basic
diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated
Contrast Media used for cardiovascular system CT and digital subtraction
angiography are all water-soluble organic iodinated contrast materials.

Finished Types of Contrast Media

S. No Product name Characteristic Specification
1 Gadopentetate Dimeglumine Injection Injectable solution
469mg/ml:  10ml, 12ml, 15ml, 20ml
2 Gadobutrol Injection Injectable solution 604.72mg/ml:  7.5ml
3 Ammonium iron citrate Oral granules 3g:0.6g(Fe 129mg)
6g:1.2g(Fe 258mg)
4 Iopamidol Injection Injectable solution 300mgI/ml:  50ml,
100ml
370mgI/ml:  50ml, 100ml
5 Iodixanol Injection Injectable solution 270mgI/ml:  100ml
320mgI/ml:  50ml, 100ml
6 Iohexol Injection Injectable solution 300mgI/ml:
 20ml,50ml,75ml, 100ml
350mgI/ml:  20ml, 50ml, 100ml

API & Intermediates Types of Contrast Media

S. No Products CAS NO. Packings Classification
1 Iohexol 66108-95-0 25kg Contrast agent
2 Iodixanol 92339-11-2 25kg Contrast agent
3 Iopromide  73334-07-3 25kg Contrast agent
4 Iopamidol 60166-93-0 25kg Contrast agent
5 Ioversol 87771-40-2 25kg Contrast agent
6 Gadopentetate Monomeglumine 92923-57-4 25kg Contrast agent
7 Gadopentetate Dimeglumine 86050-77-3 25kg Contrast agent
8 Gadobutrol 138071-82-6 25kg Contrast agent
9 Calcobutrol 151878-23-8 2kg Excipients
10 Repaglinide 135062-02-1 10kg Anti-diabetic
11 Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA) 67-43-6
2.5kg Intermediates
12 Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic
acid 35453-19-1 25kg Intermediates

Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media
(Concentration:mg(I)/ml) Osmotic pressure
(mOsm/kg water) Viscosity
(cP,37℃)
Iopamidol 300 616 4.7
Ioverol 300 651 5.5
Iohexol 300 672 6.3
Iobitridol 300 695 6
Iodixanol 320 290 11.8

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative
viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-
2.4.

Three factors of renal injury induced by Contrast Media: Osmotic pressure,
Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to
avoid kidney damage.

Beilu is a professional contrast media companies, we provide ct contrast agent,
mri contrast medium, contrast media products and etc. Want to know more? Please
contact us.

Minimum Order: 20 pieces

Contrast Media Manufacturing Company
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