Buy YK11/Sarm YK11 US with High Quality CAS:431579-34-9

Product Name: YK11/Sarm YK11
CAS: 431579-34-9
Purity: 99% HPLC
Appearance: white powder
Package: 10g/bag or as customers'request.
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Lead time:7-15 days after payment
Safe shipping to most countries like USA, UK, Australia etc.



What is Myostatin？
Myostatin is also known as GDF8(growth Differentiation factor 8). In a 1997
experimental report, Mcpherron et al. demonstrated the biological effects of
targeted disruption of the mouse growth and differentiation factor 8(GDF8)
gene. Mice deficient in GDF8 had significantly larger body size than wild-
type mice and generally increased skeletal muscle mass. The weight of single
muscle in mice lacking GDF8 gene expression is 2-3 times that of wild mice,
and the increase of muscle mass is the result of muscle hypertrophy and
hyperplasia. These experiments established that GDF8 peptide is the main
participant in inhibiting muscle growth, which was named Myostain. So
myostatin is also known as GDF8.

Myostatin is a member of the transforming growth factor-β (TGF-β)
superfamily of signal peptides, which is specifically expressed in
developing and adult skeletal muscle.

Myostatin expression limits muscle size during development, consistent with
multiple factors that shape bones, blood vessels, and limbs associated with
ectodermal growth patterns. Myoblasts regulate the expression of PAX-3 and
MYF-5, important transcription factors for myoblast proliferation, and myO-
D, which promotes muscle differentiation. In response to myostatin, which
inhibits muscle production and differentiation.

Myostatin regulates the growth and differentiation of muscle cells and
limits the growth of skeletal muscle to prevent muscle from becoming too
large.

This may be related to the body's self-regulation, its own muscles, need a
lot of calories and protein to maintain, the more muscle production, need to
eat more calories and protein, this may be against "frugality", so myostatin
limits muscle production and development.

This also explains why the muscle gained on a low-calorie diet is used up,
because our bodies assume that we don't have enough food and, in order to
help us live longer, break down the muscle tissue groups that use more
energy.

In fact, muscle is not the most energy-consuming tissue in the body. The
proper functioning of basic organs such as the brain, heart, liver and
kidneys uses about 58 percent of energy, muscle about 22 percent, fat about
5 percent, and the remaining 16 percent includes our skin, bones and other
internal organs. But the brain, heart, liver, skin and internal organs must
take priority, so the body has to work with a larger proportion of muscle
tissue.

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