139755-83-2 Male Aphrodisiac Powder Dudley Alkaloids 99% Purity Demecolcine

Dudley Alkaloids An Aphrodisiac Sildenafil Powder It Is Used To Treat Erectile
Dysfunction In Men



1. Product title: Demecolcine





2.Product parameter table:



Product Name Dudley alkaloids Specification 99%
Appearance White or light white power Main Effect An aphrodisiac
Brand Name Kan Ying Store-method Cool Dry Place
Shelf Life 2 Years When
Properly Stored From India



3. Product Description:



Sildenafil is a selective type 5 phosphodiesterase (PDE5) inhibitor specific for
cyclic guanosine phosphate (cGMP). It can be used to treat erectile dysfunction
(ED).

1. Mechanism of action The physiological mechanism of penile erection involves the
release of nitric oxide (NO) in the sponges of the penis during sexual stimulation.
NO activates guanylate cyclase to increase cGMP levels, which relaxes the smooth
muscle and fills the blood.

2. Pharmacodynamics



(1) Effect of sildenafil on penile erectile response. Sildenafil is a highly
selective phosphodiesterase 5(PDE5) inhibitor, which is highly expressed in the
cavernous body of the penis and is low expressed in other tissues, including
platelets, blood vessels and visceral smooth muscle, and skeletal muscle.
Sildenafil can selectively inhibit PDE5, enhance the nitric oxide (NO)-cGMP
pathway, and increase the level of cGMP, resulting in the relaxation of the
cavernosial smooth muscle of the penis, so that patients with erectile dysfunction
can produce a natural erectile response to sexual stimulation. Erectile response is
generally enhanced with increasing sildenafil dose and plasma concentration.
Experiments showed that the effect lasted up to 4 hours, but the response was
weaker than that at 2 hours.



(2) Response of sildenafil to myocardium. PDE5 does not exist in normal or
pathological cardiac conduction tissues, cardiomyocytes, endothelial cells, and
lymphoid tissues. Therefore, sildenafil (PDE5 inhibitor) has no positive inotropic
effect and cannot directly affect myocardial systolic function.



(3) The effect of sildenafil on cardiac parameters. No clinically significant ECG
changes were observed in normal male volunteers with a single dose of sildenafil
100mg. Eight patients with stable ischemic heart disease received a total of 40mg
of sildenafil in four intravenous doses monitored by a Swan-Ganz catheter. Systolic
and diastolic blood pressure at rest decreased by 7% and 10%, respectively, from
baseline. Rest right atrium, pulmonary artery pressure, pulmonary wedge pressure,
and cardiac output decreased by an average of 28%, 28%, 20%, and 7%, respectively.
Although this intravenous dose was 2 to 5 times higher than the average peak plasma
concentration of 100mg of sildenafil in a single dose of oral sildenafil in healthy
male volunteers, these hemodynamic responses remained during exercise.





4.Pictures of the product:



139755-83-2 Male Aphrodisiac Powder Dudley Alkaloids 99% Purity Demecolcine
0139755-83-2 Male Aphrodisiac Powder Dudley Alkaloids 99% Purity Demecolcine 1

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